Multiple sclerosis showing elevation of adenosine deaminase levels in the cerebrospinal fluid

被引：11

作者：

Samuraki, Miharu ^{[1
]}

Sakai, Kenji ^{[1
]}

Odake, Yasuko ^{[3
]}

Yoshita, Mitsuhiro ^{[3
]}

Misaki, Kouichi ^{[2
]}

Nakada, Mitsutoshi ^{[2
]}

Yamada, Masahito ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Dept Neurol & Neurobiol Aging, Kanazawa, Ishikawa, Japan

[2] Kanazawa Univ, Dept Neurosurg, Kanazawa, Ishikawa, Japan

[3] Hokuriku Univ, Natl Hosp Org, Dept Neurol, Kanazawa, Ishikawa, Japan

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2017年 / 13卷

关键词：

Multiple sclerosis; Adenosine deaminase; Tuberculosis; Cerebrospinal fluid; Brain biopsy;

D O I：

10.1016/j.msard.2017.02.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

An 80-year-old man developed dysarthria, quadriplegia, sensory disturbance and ataxia in all limbs. Brain and spinal magnetic resonance imaging (MRI) revealed multiple enhanced lesions. Cerebrospinal fluid (CSF) levels of adenosine deaminase (ADA) remarkably elevated. Tuberculosis DNA was not detected, and tuberculosis was not cultured either in the CSF. Brain biopsy revealed the inflammatory demyelinating lesions. With the diagnosis of multiple sclerosis, corticosteroid therapy resulted in rapid improvement of his symptoms and MRI abnormalities. CSF levels of ADA also decreased. Multiple sclerosis should be included in differential diagnosis of disorders with ADA elevation in the CSF.

引用

页码：44 / 46

页数：3

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