Multiple sclerosis showing elevation of adenosine deaminase levels in the cerebrospinal fluid

被引：11

作者：

Samuraki, Miharu ^{[1
]}

Sakai, Kenji ^{[1
]}

Odake, Yasuko ^{[3
]}

Yoshita, Mitsuhiro ^{[3
]}

Misaki, Kouichi ^{[2
]}

Nakada, Mitsutoshi ^{[2
]}

Yamada, Masahito ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Dept Neurol & Neurobiol Aging, Kanazawa, Ishikawa, Japan

[2] Kanazawa Univ, Dept Neurosurg, Kanazawa, Ishikawa, Japan

[3] Hokuriku Univ, Natl Hosp Org, Dept Neurol, Kanazawa, Ishikawa, Japan

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2017年 / 13卷

关键词：

Multiple sclerosis; Adenosine deaminase; Tuberculosis; Cerebrospinal fluid; Brain biopsy;

D O I：

10.1016/j.msard.2017.02.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

An 80-year-old man developed dysarthria, quadriplegia, sensory disturbance and ataxia in all limbs. Brain and spinal magnetic resonance imaging (MRI) revealed multiple enhanced lesions. Cerebrospinal fluid (CSF) levels of adenosine deaminase (ADA) remarkably elevated. Tuberculosis DNA was not detected, and tuberculosis was not cultured either in the CSF. Brain biopsy revealed the inflammatory demyelinating lesions. With the diagnosis of multiple sclerosis, corticosteroid therapy resulted in rapid improvement of his symptoms and MRI abnormalities. CSF levels of ADA also decreased. Multiple sclerosis should be included in differential diagnosis of disorders with ADA elevation in the CSF.

引用

页码：44 / 46

页数：3

共 50 条

[1] A spectrum of neurological diseases with elevated cerebrospinal fluid adenosine deaminase levels
Handa, Hideo
Uzawa, Akiyuki
Sugiyama, Atsuhiko
Yokota, Hajime
Yasuda, Manato
Kimura, Akio
Shimohata, Takayoshi
Kuwabara, Satoshi
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2025, 469
[2] Cerebrospinal fluid adenosine deaminase for the diagnosis of tuberculous meningitis
Pannu, Ashok K.
Selvam, Suresh
Rahman, Nadim
Kumar, Devender
Saroch, Atul
Sharma, Arun K.
Sethi, Sunil
Yadav, Rakesh
Bhatia, Vikas
BIOMARKERS IN MEDICINE, 2023, 17 (04) : 209 - 218
[3] Adenosine deaminase and xanthine oxidase levels in multiple sclerosis patients
Gokce, Seyda Figul
Demirpence, Ozlem
Cigdem, Burhanettin
Bolayir, Asli
Ersan, Serpil
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, 2020, 11 : 147 - 150
[4] Cerebrospinal fluid nitrate levels in patients with multiple sclerosis
de Bustos, F
Navarro, JA
de Andrés, C
Molina, JA
Jiménez-Jiménez, FJ
Ortí-Pareja, M
Gasalla, T
Tallón-Barranco, A
Martínez-Salio, A
Arenas, J
EUROPEAN NEUROLOGY, 1999, 41 (01) : 44 - 47
[5] Cerebrospinal fluid pleocytosis in multiple sclerosis patients with lesions showing reduced diffusion
Eisele, Philipp
Szabo, Kristina
Griebe, Martin
Wolf, Marc E.
Hennerici, Michael G.
Gass, Achim
MULTIPLE SCLEROSIS JOURNAL, 2014, 20 (10) : 1391 - 1395
[6] Increased glycine levels in cerebrospinal fluid of patients with multiple sclerosis
Durfinova, Monika
Bartova, Radka
Oresanska, Katarina
Turecky, Ladislav
Prochazkova, L'ubica
Petrlenicova, Darina
Liska, Branislav
CLINICA CHIMICA ACTA, 2018, 486 : 86 - 87
[7] Cerebrospinal fluid mitochondrial DNA levels in patients with multiple sclerosis
Fissolo, Nicolas
Cervera-Carles, Laura
Villar Guimerans, Luisa Maria
Lleo, Alberto
Clarimon, Jordi
Drulovic, Jelena
Dujmovic, Irena
Voortman, Margarete
Khalil, Michael
Gil, Elia
Navarro, Laura
Carlos Alvarez-Cermeno, Jose
Montalban, Xavier
Comabella, Manuel
MULTIPLE SCLEROSIS JOURNAL, 2019, 25 (11) : 1535 - 1538
[8] Cerebrospinal fluid in multiple sclerosis
Rammohan, Kottil W.
ANNALS OF INDIAN ACADEMY OF NEUROLOGY, 2009, 12 (04) : 246 - 253
[9] Adenosine deaminase levels in cerebrospinal fluid as a diagnostic test for tuberculous meningitis in children
Rana S.V.
Singhal R.K.
Singh K.
Kumar L.
Indian Journal of Clinical Biochemistry, 2004, 19 (2) : 5 - 9
[10] Cryptococcal meningitis associated with increased adenosine deaminase in the cerebrospinal fluid
Tanaka, Yuji
Satomi, Kazuo
SPRINGERPLUS, 2016, 5

← 1 2 3 4 5 →