Cerebrospinal fluid anti-SSA autoantibodies in primary Sjogren's syndrome with central nervous system involvement

被引：15
作者：
Megevand, Pierre
Chizzolini, Carlo
Chofflon, Michel
Roux-Lombard, Pascale
Lalive, Patrice H.
Picard, Fabienne
机构：
[1] Univ Hosp Geneva, Serv Neurol, Dept Clin Neurosci & Dermatol, Geneva, Switzerland
[2] Univ Hosp Geneva, Serv Immunol & Allergy, Dept Internal Med, Geneva, Switzerland
[3] Univ Geneva, Sch Med, CH-1211 Geneva, Switzerland
来源：
EUROPEAN NEUROLOGY | 2007年 / 57卷 / 03期
关键词：
Sjogren's syndrome; central nervous system; cerebrospinal fluid; immunoglobulin G; anti-SSA autoantibodies; intrathecal synthesis;
D O I：
10.1159/000098469
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Central nervous system involvement in primary Sjogren's syndrome is a matter of controversy, and its diagnosis remains difficult. Methods: We report 3 patients with primary Sjogren's syndrome and central nervous system involvement in whom we assessed intrathecal immunoglobulin G synthesis and the presence of cerebrospinal fluid anti-SSA and anti-SSB autoantibodies. Results: We found intrathecal immunoglobulin G synthesis and presence of cerebrospinal fluid anti-SSA autoantibodies in all patients, with demonstration for the first time of specific anti-SSA autoantibody intrathecal synthesis in 2 patients. Conclusion: We suggest that cerebrospinal fluid anti-SSA autoantibodies could serve as a biomarker for Sjogren's-syndrome-related central nervous system involvement. Copyright (c) 2007 S. Karger AG, Basel.
引用
收藏
页码：166 / 171
页数：6
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