The development of neutralizing antibodies against SARS-CoV-2 and their common features

被引：14
作者：
Liu, Liu Daisy [1 ,2 ]
Lian, Chaoyang [3 ]
Yeap, Leng-Siew [3 ]
Meng, Fei-Long [1 ,2 ]
机构：
[1] Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China
[2] Univ Chinese Acad Sci, Shanghai 200031, Peoples R China
[3] Shanghai Jiao Tong Univ, Shanghai Inst Immunol, Dept Immunol & Microbiol, State Key Lab Oncogenes & Related Genes,Sch Med, Shanghai 200025, Peoples R China
来源：
JOURNAL OF MOLECULAR CELL BIOLOGY | 2020年 / 12卷 / 12期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
COVID-19; SARS-CoV-2; neutralizing antibody; epitope; RBD; HUMAN MONOCLONAL-ANTIBODIES; POTENT NEUTRALIZATION; B-CELLS; RECEPTOR; SPIKE;
D O I：
10.1093/jmcb/mjaa070
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide severe coronavirus disease 2019 (COVID-19) pandemic since December 2019. There is a great demand for effective therapies for the prevention and treatment of COVID-19. Developing therapeutic neutralizing antibodies (NAbs), which could block viral infection, is such a promising approach, as NAbs have been successfully applied to the treatment of other viral infections. The recent advances of antibody technology have greatly accelerated the discovery of SARS-CoV-2 NAbs, and many of which are now actively tested in clinical trials. Here, we review the approaches applied for SARS-CoV-2 NAb development, and discuss the emerging technologies underlining the antibody discovery. We further summarize the common features of these antibodies including the shared neutralizing epitopes and sequence features.
引用
收藏
页码：980 / 986
页数：7
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