Divalproex Sodium-Induced Eosinophilic Pleural Effusion

被引：11

作者：

Joshi, Prachi ^{[1
]}

Kasmani, Rahil ^{[2
]}

Hollingsworth, Jocelyn ^{[4
]}

Fernandes, Karl ^{[3
]}

Mahajan, Kewal ^{[2
]}

机构：

[1] St Vincent Mercy Med Ctr, Dept Family Med, Toledo, OH USA

[2] St Vincent Mercy Med Ctr, Dept Internal Med, Toledo, OH USA

[3] St Vincent Mercy Med Ctr, Dept Pulm & Crit Care Med, Toledo, OH USA

[4] Med Coll Ohio, Toledo, OH 43699 USA

来源：

AMERICAN JOURNAL OF THERAPEUTICS | 2009年 / 16卷 / 06期

关键词：

eosinophil; valproic acid; pleural effusion; VALPROIC ACID;

D O I：

10.1097/MJT.0b013e3181921188

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Eosinophilic pleural effusion is defined as an effusion in which eosinophils constitute more than 10% of white blood cells. These effusions can be due to multiple causes with drugs being implicated as one of the etiological agents. We report a case of 48-year-old woman with seizure disorder on divalproex sodium (Depakote) who presented with dyspnea. A chest radiograph demonstrated right pleural effusion. Investigations showed peripheral blood eosinophilia with thoracocentesis revealing eosinophilic exudative pleural effusion. An extensive workup for other causes of eosinophilic pleural effusion was unrevealing. Withdrawal of Depakote resulted in resolution of the effusion.

引用

页码：593 / 595

页数：3