Paraoxonase and other coronary risk factors in a community-based cohort

被引：9
作者：
Cohen, J
Jenkins, AJ
Karschimkus, C
Qing, S
Lee, CT
O'Dea, K
Best, JD
Rowley, KG
机构：
[1] Univ Melbourne, Dept Med, Fitzroy, Vic 3065, Australia
[2] Univ N Carolina, Sch Med, Chapel Hill, NC USA
[3] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3168, Australia
[4] Menzies Sch Hlth Res, Casuarina, NT, Australia
来源：
REDOX REPORT | 2002年 / 7卷 / 05期
关键词：
D O I：
10.1179/135100002125000848
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxidative damage to circulating lipids and vascular tissues contributes to the initiation and progression of atherosclerosis. High density lipoprotein provides protection from atherosclerosis and the enzyme paraoxonase may contribute to this effect. The aim of the present study was to examine the trends in paraoxonase activity during the course of a community-directed life-style intervention, and relationships of paraoxonase activity to other coronary heart disease risk factors, in a cohort of Australian Aboriginal people.
引用
收藏
页码：304 / 307
页数：4
相关论文
共 15 条
[1]   Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants [J].
Aviram, M ;
Rosenblat, M ;
Billecke, S ;
Erogul, J ;
Sorenson, R ;
Bisgaier, CL ;
Newton, RS ;
La Du, B .
FREE RADICAL BIOLOGY AND MEDICINE, 1999, 26 (7-8) :892-904
[2]   Blood radicals - Reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system [J].
DarleyUsmar, V ;
Halliwell, B .
PHARMACEUTICAL RESEARCH, 1996, 13 (05) :649-662
[3]  
ECKERSON HW, 1983, AM J HUM GENET, V35, P1126
[4]  
GAN KN, 1991, DRUG METAB DISPOS, V19, P100
[5]   Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation [J].
Hayek, T ;
Fuhrman, B ;
Vaya, J ;
Rosenblat, M ;
Belinky, P ;
Coleman, R ;
Elis, A ;
Aviram, M .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (11) :2744-2752
[6]   Calcium-dependent human serum homocysteine thiolactone hydrolase -: A protective mechanism against protein N-homocysteinylation [J].
Jakubowski, H .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (06) :3957-3962
[7]   Genetic determinants of homocysteine thiolactonase activity in humans: implications for atherosclerosis [J].
Jakubowski, H ;
Ambrosius, WT ;
Pratt, JH .
FEBS LETTERS, 2001, 491 (1-2) :35-39
[8]   On the physiological role(s) of the paraoxonases [J].
La Du, BN ;
Aviram, M ;
Billecke, S ;
Navab, M ;
Primo-Parmo, S ;
Sorenson, RC ;
Standiford, TJ .
CHEMICO-BIOLOGICAL INTERACTIONS, 1999, 119 :379-388
[9]   Paraoxonase status in coronary heart disease - Are activity and concentration more important than genotype? [J].
Mackness, B ;
Davies, GK ;
Turkie, W ;
Lee, E ;
Roberts, DH ;
Hill, E ;
Roberts, C ;
Durrington, PN ;
Mackness, MI .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (09) :1451-1457
[10]   How high-density lipoprotein protects against the effects of lipid peroxidation [J].
Mackness, MI ;
Durrington, PN ;
Mackness, B .
CURRENT OPINION IN LIPIDOLOGY, 2000, 11 (04) :383-388
12