LncRNA MALAT1: A Potential Fibrosis Biomarker and Therapeutic Target

被引：4
|
作者：
Li, Yijie [1 ,2 ,3 ,4 ,5 ]
Liu, Fenglin [6 ]
Cai, Yunzhou [1 ,2 ,3 ,4 ,5 ]
Yang, Yanqing [1 ,2 ,3 ,4 ,5 ]
Wang, Yuehong [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Cent South Univ, Hunan Key Lab Oral Hlth Res, Changsha 410008, Peoples R China
[2] Cent South Univ, Hunan 3D Printing Engn Res Ctr Oral Care, Changsha 410008, Peoples R China
[3] Cent South Univ, Hunan Clin Res Ctr Oral Major Dis & Oral Hlth, Changsha 410008, Peoples R China
[4] Cent South Univ, Academician Workstn Oral Maxillofacial & Regenera, Changsha 410008, Peoples R China
[5] Cent South Univ, Xiangya Sch Stomatol, Changsha 410008, Peoples R China
[6] Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Peoples R China
来源：
CRYSTALS | 2021年 / 11卷 / 03期
基金：
中国国家自然科学基金;
关键词：
fibrosis; long noncoding RNAs; MALAT1; pathogenic mechanism; LONG NONCODING RNA; TO-MESENCHYMAL TRANSITION; INDUCED INTERSTITIAL FIBROSIS; METABOLOMICS; INJURY; INFLAMMATION; SUPPRESSION; DYSFUNCTION; MECHANISMS; REGULATOR;
D O I：
10.3390/cryst11030249
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
Due to the lack of an effective method for the treatment of fibrosis, there are numerous patients suffering from the effects of fibrosis. Severe fibrosis can cause dysfunction of relevant organs characterized by excessive deposition of extracellular matrix components. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA that is widely expressed and highly conserved in human tissues. It can regulate gene expression at various molecular levels, involved in the fibrosis of the liver, heart, lung, and kidney. In this review, we first described the pathogenesis by which MALAT1 promotes fibrosis. Furthermore, we summarized current studies of MALAT1 in the fibrosis of various organs. Hope this review will contribute to a better understanding of the molecular mechanism of fibrosis and the potential of MALAT1 as a novel therapeutic target for fibrosis.
引用
收藏
页码：1 / 16
页数：16
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