Traumatic Brain Injuries during Development: Implications for Alcohol Abuse

被引：17
作者：
Weil, Zachary M. [1 ]
Karelina, Kate [1 ]
机构：
[1] Ohio State Univ, Dept Neurosci, Behav Neuroendocrinol Grp, Ctr Brain & Spinal Cord Repair,Wexner Med Ctr, Columbus, OH 43210 USA
来源：
FRONTIERS IN BEHAVIORAL NEUROSCIENCE | 2017年 / 11卷
基金：
美国国家卫生研究院;
关键词：
alcohol; traumatic brain injury; dopamine; inflammation; adolescent; POSTTRAUMATIC-STRESS-DISORDER; DRUG-USE; SUBSTANCE-ABUSE; ETHANOL; ADOLESCENTS; ASSOCIATION; CHILDHOOD; OUTCOMES; HISTORY; RISK;
D O I：
10.3389/fnbeh.2017.00135
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Traumatic brain injuries are strongly related to alcohol intoxication as by some estimates half or more of all brain injuries involve at least one intoxicated individual. Additionally, there is mounting evidence that traumatic brain injuries can themselves serve as independent risk factors for the development of alcohol use disorders, particularly when injury occurs during juvenile or adolescent development. Here, we will review the epidemiological and experimental evidence for this phenomenon and discuss potential psychosocial mediators including attenuation of negative affect and impaired decision making as well as neurochemical mediators including disruption in the glutamatergic, GABAergic, and dopaminergic signaling pathways and increases in inflammation.
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页数：8
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