4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1

被引：294

作者：

Lee, HW

Park, SJ

Choi, BK

Kim, HH

Nam, KO

Kwon, BS ^{[1
]}

机构：

[1] Univ Ulsan, Immunomodulat Res Ctr, Ulsan 680749, South Korea

[2] Louisiana State Univ, Ctr Eye, Hlth Sci Ctr, Sch Med, New Orleans, LA 70112 USA

来源：

JOURNAL OF IMMUNOLOGY | 2002年 / 169卷 / 09期

关键词：

D O I：

10.4049/jimmunol.169.9.4882

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

4-1BB, a T cell costimulatory receptor, prolongs CD8(+) Tcell survival. In these studies, 4-1BB stimulation was shown to increase expression of the antiapoptotic genes bcl-x(L) and bfl-1 via 4-1BB-mediated NF-kappaB activation. This signaling pathway was specifically inhibited by PDTC and was different from the pathways that enhanced CD8(+) T cell proliferation. The results suggest a role for the antiapoptotic activities of Bcl-x(L) and Bfl-1 proteins in 4-1BB-mediated CD8(+) T cell survival in vivo.

引用

收藏

页码：4882 / 4888

页数：7

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