Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A

被引：12

作者：

Komatsu, Sachiko ^{[1
]}

Sasano, Yusuke ^{[2
]}

Sugiyama, Kyoko ^{[1
]}

Watanabe, Kazuhiro ^{[1
]}

Kumano, Masayuki ^{[2
]}

Yoshida, Kentaro ^{[3
]}

Ono, Tetsuya ^{[3
]}

Iwabuchi, Yoshiharu ^{[2
]}

Fujimura, Tsutomu ^{[1
]}

Sato, Katsuhiko ^{[1
,4
]}

Kashiwagi, Yoshitomo ^{[3
]}

机构：

[1] Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan

[2] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, 6-3 Aoba, Sendai, Miyagi 9808578, Japan

[3] Ohu Univ, Sch Pharmaceut Sci, 31-1 Misumido,Tomita Machi, Koriyama, Fukushima 9638611, Japan

[4] Natl Inst Technol, Tsuruoka Coll, Dept Creat Engn, 104 Sawada, Tsuruoka, Yamagata 9978511, Japan

来源：

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE | 2021年 / 16卷 / 02期

基金：

日本学术振兴会;

关键词：

nitroxyl radical; TEMPO; cyclosporine A; sensor; OXIDATION; ALCOHOLS; AZADO; IMMUNOSUPPRESSANTS; ACID;

D O I：

10.20964/2021.02.30

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

Nitroxyl radical catalysts oxidize alcohols under an applied electric potential. It is possible to quantify the alcohol concentration from the resulting oxidation current. In this work, we evaluated the catalytic activity of nitroxyl radicals (or their corresponding hydroxylamines), including 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) as representative nitroxyl radicals, acetoamido-TEMPO, which shows higher oxidation potential than TEMPO owing to the acetoamido group, AZADO, Nor-AZADO, and NNO as less-hindered bicyclic nitroxyl radicals, and NHPI as an N,N-diacyl-type hydroxylamine, in acetonitrile solution. TEMPO, AZADO and NNO were also evaluated for their ability to oxidize alcohols in organic solvents, and their reactivity was compared with the electrochemical response. The most active NNO was used for electrochemical detection of cyclosporin A, a drug with a hydroxyl group. An abstract stating the features and drawing attention to the novel aspects.

引用

页码：1 / 9

页数：9

共 31 条

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