Anticancer activity of artemisinin-derived trioxanes

被引：39
作者：
Posner, Gary H. [1 ]
D'Angelo, John [1 ]
O'Neill, Paul M. [1 ]
Mercer, Amy [1 ]
机构：
[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2006年 / 16卷 / 12期
基金：
美国国家卫生研究院;
关键词：
artemisinin; dimers; endoperoxides; trioxanes;
D O I：
10.1517/13543776.16.12.1665
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The recent scientific and patent literature on therapeutically promising anticancer trioxanes derived from the antimalarial artemisinin are reviewed through mid-2006. Several of these new chemical entities, especially some trioxane dimers, have selective and very potent anticancer activity even at low nanomolar concentrations. A major opportunity exists for the development of these and related trioxanes into anticancer drug candidates.
引用
收藏
页码：1665 / 1672
页数：8
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