Will allogeneic CAR T cells for CD19+ malignancies take autologous CAR T cells 'off the shelf'?

被引：31
作者：
DiNofia, Amanda M. [1 ,2 ]
Grupp, Stephan A. [1 ,2 ]
机构：
[1] Childrens Hosp Philadelphia, Cellular Therapy & Transplant Sect, Canc Immunotherapy Program, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Pediat, Div Oncol, Perelman Sch Med, Philadelphia, PA 19104 USA
来源：
NATURE REVIEWS CLINICAL ONCOLOGY | 2021年 / 18卷 / 04期
关键词：
D O I：
10.1038/s41571-021-00485-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The question of whether allogeneic chimeric antigen receptor (CAR) T cells could replace autologous CAR T cell therapy has garnered considerable interest, but limited data have been available for comparisons to date. Now, Benjamin et al. have reported their experience with allogeneic anti-CD19 CAR T cells in 21 paediatric and adult patients with acute lymphoblastic leukaemia.
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页码：195 / 196
页数：2
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