Prodigiosin induces caspase-9 and caspase-8 activation and cytochrome C release in Jurkat T cells

被引：11

作者：

Montaner, B ^{[1
]}

Pérez-Tomas, R ^{[1
]}

机构：

[1] Univ Barcelona, Dept Biol Cellular & Anat Patol, Canc Cell Biol Res Grp, E-08907 Lhospitalet De Llobregat, Barcelona, Spain

来源：

CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS | 2002年 / 973卷

关键词：

apoptosis; caspases; cytochrome c; prodigiosin;

D O I：

10.1111/j.1749-6632.2002.tb04642.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prodigiosin (PG) is an active component of bacterial origin, with reported apoptotic effects. We examined the activation of caspases-9, -8, and -3 in PG-treated Jurkat cells in a dose-response study. These caspases were activated in apoptotic cells, as judged by the appearance of cleavage products from procaspases, and cytochrome c (cyt c) was released to the cytosol. In addition, PG induced the cleavage of poly (ADP-ribose) polymerase (PARP). This study demonstrates that the activation of caspases-9, -8, and -3 mediates PG-induced apoptosis.

引用

页码：246 / 249

页数：4

共 50 条

[1] ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation
Jimbo, A
Fujita, E
Kouroku, Y
Ohnishi, J
Inohara, N
Kuida, K
Sakamaki, K
Yonehara, S
Momoi, T
EXPERIMENTAL CELL RESEARCH, 2003, 283 (02) : 156 - 166
[2] Camalexin induces apoptosis in T-leukemia Jurkat cells by increased concentration of reactive oxygen species and activation of caspase-8 and caspase-9
Mezencev, Roman
Updegrove, Taylor
Kutschy, Peter
Repovska, Maria
McDonald, John F.
JOURNAL OF NATURAL MEDICINES, 2011, 65 (3-4) : 488 - 499
[3] Activation of Caspase-9, but Not Caspase-2 or Caspase-8, Is Essential for Heat-induced Apoptosis in Jurkat Cells
Shelton, Shary N.
Dillard, Cindy D.
Robertson, John D.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (52) : 40525 - 40533
[4] Camalexin induces apoptosis in T-leukemia Jurkat cells by increased concentration of reactive oxygen species and activation of caspase-8 and caspase-9
Roman Mezencev
Taylor Updegrove
Peter Kutschy
Mária Repovská
John F. McDonald
Journal of Natural Medicines, 2011, 65 : 488 - 499
[5] Cytochrome c release is upstream to activation of caspase-9, caspase-8, and caspase-3 in the enhanced apoptosis of anaplastic thyroid cancer cells induced by manumycin and paclitaxel
Pan, JX
Xu, GP
Yeung, SCJ
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (10): : 4731 - 4740
[6] γ-Tocopheryl quinone induces apoptosis in cancer cells via caspase-9 activation and cytochrome c release
Calviello, G
Di Nicuolo, F
Piccioni, E
Marcocci, ME
Serini, S
Maggiano, N
Jones, KH
Cornwell, DG
Palozza, P
CARCINOGENESIS, 2003, 24 (03) : 427 - 433
[7] Ginsenoside Rh2 Induces Human Hepatoma Cell Apoptosis via Bax/Bak Triggered Cytochrome C Release and Caspase-9/Caspase-8 Activation
Guo, Xiao-Xi
Guo, Qiao
Li, Yang
Lee, Seung Ki
Wei, Xue-Ning
Jin, Ying-Hua
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2012, 13 (12) : 15523 - 15535
[8] Progesterone induces apoptosis by activation of caspase-8 and calcitriol via activation of caspase-9 pathways in ovarian and endometrial cancer cells in vitro
McGlorthan, Latoya
Paucarmayta, Ana
Casablanca, Yovanni
Maxwell, G. Larry
Syed, Viqar
APOPTOSIS, 2021, 26 (3-4) : 184 - 194
[9] Gamma irradiation of human leukaemic cells HL-60 and MOLT-4 induces decrease in Mcl-1 and Bid, release of cytochrome c, and activation of caspase-8 and caspase-9
Tichy, Ales
Zaskodova, Darina
Pejchal, Jaroslav
Rezacova, Martina
Oeterreicher, Jan
Vavrova, Jirina
Cerman, Jarsolav
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2008, 84 (06) : 523 - 530
[10] The equine arteritis virus induces apoptosis via caspase-8 and mitochondria-dependent caspase-9 activation
St-Louis, Marie-Claude
Archambault, Denis
VIROLOGY, 2007, 367 (01) : 147 - 155

← 1 2 3 4 5 →