Outcomes in prediabetes vs. diabetes in patients with non-ST-segment elevation myocardial infarction undergoing percutaneous intervention

被引:2
|
作者
Kim, Yong Hoon [1 ]
Her, Ae-Young [1 ]
Jeong, Myung Ho [2 ]
Kim, Byeong-Keuk [3 ]
Hong, Sung-Jin [3 ]
Kim, Seunghwan [4 ]
Ahn, Chul-Min [3 ]
Kim, Jung-Sun [3 ]
Ko, Young-Guk [3 ]
Choi, Donghoon [3 ]
Hong, Myeong-Ki [3 ]
Jang, Yangsoo [3 ]
机构
[1] Kangwon Natl Univ, Dept Internal Med, Div Cardiol, Sch Med, 156 Baengnyeong Rd, Chunchon 24289, Gangwon Provinc, South Korea
[2] Chonnam Natl Univ Hosp, Cardiovasc Ctr, Dept Cardiol, Gwangju, South Korea
[3] Yonsei Univ, Severance Cardiovasc Hosp, Div Cardiol, Coll Med, Seoul, South Korea
[4] Inje Univ, Haeundae Paik Hosp, Div Cardiol, Coll Med, Busan, South Korea
关键词
diabetes; multivessel disease; non-ST-segment elevation myocardial infarction; prediabetes; CORONARY-ARTERY-DISEASE; UNITED-STATES; RISK-FACTOR; MELLITUS; MULTIVESSEL; MORTALITY; METAANALYSIS; DYSFUNCTION; IMPACT;
D O I
10.1097/MCA.0000000000000969
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective The comparative long-term clinical outcomes between patients with prediabetes and diabetes in patients with non-ST-elevation myocardial infarction (NSTEMI) and multivessel disease (MVD) who were undergoing percutaneous coronary intervention (PCI) are not well known. We therefore compared the 2-year clinical outcomes in such patients. Methods A total of 2963 patients with NSTEMI and MVD [normoglycemia (group A, n = 629), prediabetes (group B, n = 802), and diabetes (group C, n = 1532)] were evaluated. The primary outcomes were the occurrence of major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (Re-MI), and any repeat revascularization. The secondary outcome was stent thrombosis. Results The cumulative incidence of MACE as well as for death or MI in group B and C were similar when compared to each other. However, they (P = 0.048 and P = 0.017, respectively and P = 0.022 and P = 0.001, respectively) were significantly higher than in group A. The cumulative incidence of all-cause death in group B (P = 0.042) and all-cause death and cardiac death in group C (P = 0.001 and P = 0.028, respectively) were significantly higher than in group A. However, those of all-cause death, cardiac death, Re-MI, any repeat revascularization, and ST were not significantly different between groups B and C. Conclusion In this study, patients with NSTEMI and MVD who underwent successful implantation of newer-generation DES and were prediabetic had worse outcomes compared to normoglycemics and comparable to those with diabetes.
引用
收藏
页码:211 / 223
页数:13
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