Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium

被引：49

作者：

Santonen, Tiina ^{[1
]}

Alimonti, Alessandro ^{[2
]}

Bocca, Beatrice ^{[2
]}

Duca, Radu Corneliu ^{[3
]}

Galea, Karen S. ^{[4
]}

Godderis, Lode ^{[3
,5
]}

Goeen, Thomas ^{[6
]}

Gomes, Bruno ^{[7
]}

Hanser, Ogier ^{[8
]}

Iavicoli, Ivo ^{[9
]}

Janasik, Beata ^{[10
]}

Jones, Kate ^{[11
]}

Kiilunen, Mirja ^{[1
]}

Koch, Holger M. ^{[12
]}

Leese, Elizabeth ^{[11
]}

Leso, Veruscka ^{[9
]}

Louro, Henriqueta ^{[7
]}

Ndaw, Sophie ^{[8
]}

Porras, Simo P. ^{[1
]}

Robert, Alain ^{[8
]}

Ruggieri, Flavia ^{[2
]}

Scheepers, Paul T. J. ^{[13
]}

Silva, Maria J. ^{[7
]}

Viegas, Susana ^{[14
,15
]}

Wasowicz, Wojciech ^{[10
]}

Castano, Argelia ^{[16
]}

Sepai, Ovnair ^{[17
]}

机构：

[1] Finnish Inst Occupat Hlth, POB 18, FI-00032 Tyoterveyslaitos, Finland

[2] Ist Super Sanita, Rome, Italy

[3] Univ Leuven, Ctr Environm & Hlth, Dept Publ Hlth & Primary Care, KU Leuven, Kapucijnenvoer 35, B-3000 Leuven, Belgium

[4] Inst Occupat Med, Ctr Human Exposure Sci, Edinburgh EH14 4AP, Midlothian, Scotland

[5] External Serv Prevent & Protect Work, IDEWE, Heverlee, Belgium

[6] Friedrich Alexander Univ Erlangen Nurnberg, Inst & Outpatient Clin Occupat Social & Environm, Erlangen, Germany

[7] Univ Nova Lisboa, Lisbon & Tox Ctr Toxicogen & Human Hlth, Natl Inst Hlth Dr Ricardo Jorge, Dept Human Genet,NOVA Med Sch S, Lisbon, Portugal

[8] French Natl Res & Safety Inst, Paris, France

[9] Univ Naples Federico II, Naples, Italy

[10] Nofer Inst Occupat Med, Lodz, Poland

[11] Hlth & Safety Execut, Buxton SK17 9JN, England

[12] Ruhr Univ Bochum, Inst Prevent & Occupat Med, German Social Accid Insurance Inst, Bochum, Germany

[13] Radboudumc, Radboud Inst Hlth Sci, Nijmegen, Netherlands

[14] Univ NOVA Lisboa, Hlth & Technol Res Ctr, ESTeSL Escola Super Tecnol Saude, Inst Politecn Lisboa, P-1600560 Lisbon, Portugal

[15] Univ NOVA Lisboa, CISP, Escola Nacl Saude Publ, P-1600560 Lisbon, Portugal

[16] Inst Salud Carlos III, Madrid, Spain

[17] Publ Hlth England, London, England

来源：

ENVIRONMENTAL RESEARCH | 2019年 / 177卷

关键词：

Hexavalent chromium; Biomonitoring; Occupational exposure; Exhaled breath condensate; Welding; Electroplating; Effect markers; Multicenter study; EXHALED BREATH CONDENSATE; METAL CARCINOGENESIS; BLOOD; RISK; VALIDATION; MANGANESE; ELEMENTS; MODELS; NICKEL; URINE;

D O I：

10.1016/j.envres.2019.108583

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance human biomonitoring (HBM) across Europe. Within its remit, the project is gathering new, policy relevant, EU-wide data on occupational exposure to relevant priority chemicals and developing new approaches for occupational biomonitoring. In this manuscript, the hexavalent chromium [Cr(VI)] study design is presented as the first example of this HBM4EU approach. This study involves eight European countries and plans to recruit 400 workers performing Cr(VI) surface treatment e.g. electroplating or stainless steel welding activities. The aim is to collect new data on current occupational exposure to Cr(VI) in Europe and to test new methods for Cr biomonitoring, specifically the analysis of Cr(VI) in exhaled breath condensate (EBC) and Cr in red blood cells (RBC) in addition to traditional urinary total Cr analyses. Furthermore, exposure data will be complemented with early biological effects data, including genetic and epigenetic effects. Personal air samples and wipe samples are collected in parallel to help informing the biomonitoring results. We present standard operational procedures (SOPs) to support the harmonized methodologies for the collection of occupational hygiene and HBM samples in different countries.

引用

页数：11

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