Methods for the assessment of peripheral muscle fatigue and its energy and metabolic determinants in COPD

被引:18
作者
Rondelli, Rafaella Rezende [1 ]
Dal Corso, Simone [1 ]
Simoes, Alexandre [1 ]
Malaguti, Carla [1 ]
机构
[1] Univ Nove de Julho, Programa Mestrado Ciencias Reabilitacao, Sao Paulo, Brazil
关键词
Pulmonary disease; chronic obstructive; Neuromuscular manifestations; Muscle fatigue; Exercise tolerance; Energy metabolism; Evaluation; OBSTRUCTIVE PULMONARY-DISEASE; VASTUS LATERALIS MUSCLE; SKELETAL-MUSCLE; SYSTEMIC INFLAMMATION; MAGNETIC-RESONANCE; PERCEIVED EXERTION; OXIDATIVE STRESS; LUNG-DISEASE; EXERCISE; QUADRICEPS;
D O I
10.1590/S1806-37132009001100011
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
It has been well established that, in addition to the pulmonary involvement, COPD has systemic consequences that can lead to peripheral muscle dysfunction, with greater muscle fatigue, lower exercise tolerance and lower survival in these patients. In view of the negative repercussions of early muscle fatigue in COPD, the objective of this review was to discuss the principal findings in the literature on the metabolic and bioenergy determinants of muscle fatigue, its functional repercussions, as well as the methods for its identification and quantification. The anatomical and functional substrate of higher muscle fatigue in COPD appears to include lower levels of high-energy phosphates, lower mitochondrial density, early lactacidemia, higher serum ammonia and reduced muscle perfusion. These alterations can be revealed by contraction failure, decreased firing rates of motor units and increased recruitment of motor units in a given activity, which can be functionally detected by a reduction in muscle strength, power and endurance. This review article also shows that various types of muscle contraction regimens and protocols have been used in order to detect muscle fatigue in this population. With this understanding, rehabilitation strategies can be developed in order to improve the resistance to muscle fatigue in this population.
引用
收藏
页码:1125 / 1135
页数:11
相关论文
共 59 条
[1]   Peripheral muscle endurance and the oxidative profile of the quadriceps in patients with COPD [J].
Allaire, J ;
Maltais, F ;
Doyon, JF ;
Noël, M ;
LeBlanc, P ;
Carrier, G ;
Simard, C ;
Jobin, J .
THORAX, 2004, 59 (08) :673-678
[2]   RELIABILITY OF MEASUREMENTS OF MUSCLE STRENGTH AND VOLUNTARY ACTIVATION USING TWITCH INTERPOLATION [J].
ALLEN, GM ;
GANDEVIA, SC ;
MCKENZIE, DK .
MUSCLE & NERVE, 1995, 18 (06) :593-600
[3]  
[Anonymous], GLOB STRAT DIAGN MAN
[4]   Oxidant metabolism in chronic obstructive pulmonary disease [J].
Boots, AW ;
Haenen, GRMM ;
Bast, A .
EUROPEAN RESPIRATORY JOURNAL, 2003, 22 :14S-27S
[5]   PSYCHOPHYSICAL BASES OF PERCEIVED EXERTION [J].
BORG, GAV .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1982, 14 (05) :377-381
[6]   Respiratory muscle unloading improves leg muscle oxygenation during exercise in patients with COPD [J].
Borghi-Silva, A. ;
Oliveira, C. C. ;
Carrascosa, C. ;
Maia, J. ;
Berton, D. C. ;
Queiroga, F., Jr. ;
Ferreira, E. M. ;
Almeida, D. R. ;
Nery, L. E. ;
Neder, J. A. .
THORAX, 2008, 63 (10) :910-915
[7]   Raised CRP levels mark metabolic and functional impairment in advanced COPD [J].
Broekhuizen, R ;
Wouters, EFM ;
Creutzberg, EC ;
Schols, AMWJ .
THORAX, 2006, 61 (01) :17-22
[8]   The plasma ammonia response to cycle exercise in COPD [J].
Calvert, L. D. ;
Singh, S. J. ;
Greenhaff, P. L. ;
Morgan, M. D. ;
Steiner, M. C. .
EUROPEAN RESPIRATORY JOURNAL, 2008, 31 (04) :751-758
[9]   Kinetics of muscle deoxygenation are accelerated at the onset of heavy-intensity exercise in patients with COPD: relationship to central cardiovascular dynamics [J].
Chiappa, Gaspar R. ;
Borghi-Silva, Audrey ;
Ferreira, Leonardo F. ;
Carrascosa, Claudia ;
Oliveira, Cristino Carneiro ;
Maia, Joyce ;
Gimenes, Ana Cristina ;
Queiroga, Fernando, Jr. ;
Berton, Danilo ;
Ferreira, Eloara M. V. ;
Nery, Luis Eduardo ;
Neder, J. Alberto .
JOURNAL OF APPLIED PHYSIOLOGY, 2008, 104 (05) :1341-1350
[10]   The use of surface electromyography in biomechanics [J].
De Luca, CJ .
JOURNAL OF APPLIED BIOMECHANICS, 1997, 13 (02) :135-163