Metal-based drugs that break the rules

被引：282

作者：

Allardyce, Claire S. ^{[1
]}

Dyson, Paul J. ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

来源：

DALTON TRANSACTIONS | 2016年 / 45卷 / 08期

关键词：

ACUTE PROMYELOCYTIC LEUKEMIA; IN-VITRO; PHOTODYNAMIC THERAPY; HUMAN OVARIAN; SELECTIVE ANTICANCER; PLATINUM COMPLEXES; ANTITUMOR-ACTIVITY; PHASE I/II; NAMI-A; RUTHENIUM;

D O I：

10.1039/c5dt03919c

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Cisplatin and other platinum compounds have had a huge impact in the treatment of cancers and are applied in the majority of anticancer chemotherapeutic regimens. The success of these compounds has biased the approaches used to discover new metal-based anticancer drugs. In this perspective we highlight compounds that are apparently incompatible with the more classical (platinum-derived) concepts employed in the development of metal-based anticancer drugs, with respect to both compound design and the approaches used to validate their utility. Possible design approaches for the future are also suggested.

引用

页码：3201 / 3209

页数：9

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