Drug and gene delivery to the brain: The vascular route

被引：316

作者：

Pardridge, WM ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90024 USA

来源：

NEURON | 2002年 / 36卷 / 04期

关键词：

D O I：

10.1016/S0896-6273(02)01054-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain drug development of either small molecule or large molecule (recombinant proteins, gene medicines) neurotherapeutics has been limited, owing to the restrictive transport properties of the brain microvasculature, which forms the blood-brain barrier (BBB) in vivo. Widespread drug delivery to the brain, while not feasible via craniotomy and intracerebral injection, is possible if the drug is delivered to brain via the transvascular route through the BBB. Novel brain drug delivery and drug targeting strategies can be developed from an understanding of the molecular and cellular biology of the brain microvascular and BBB transport processes.

引用

页码：555 / 558

页数：4