Novel Ceramides from Aerial Parts of Saussurea involucrata Kar. et. Kir.

被引：16

作者：

Wu, Wei ^{[1
]}

Qu, Yang ^{[1
]}

Gao, Huiyuan ^{[1
]}

Yang, Jingyu ^{[2
]}

Xu, Jianguo ^{[3
]}

Wu, Lijun ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Dept Phytochem, Shenyang 110016, Peoples R China

[2] Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China

[3] Xinjiang Inst Mat Med, Xinjiang 830004, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2009年 / 32卷 / 09期

关键词：

Novel ceramides; Cytotoxicity; Saussurea involucrata; GUAIANOLIDES;

D O I：

10.1007/s12272-009-1906-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel ceramides, together with nine known compounds were isolated from aerial parts of the Saussurea involucrata Kar. et. Kir. The novel structures were determined by spectroscopic methods and microscale chemical degradation. The ceramides showed appreciable cytotoxicity against three human tumor cell lines including human promyelocytic leukemia (HL-60), human melanoma (A375-S2) and human cervical carcinoma (HeLa) cell lines. The results suggested that this class of ceramides may have potential as an antitumor agent.

引用

页码：1221 / 1225

页数：5

共 21 条

[1] A new ceramide from the basidiomycete Russula cyanoxantha [J].

Gao, JM ;

Dong, ZJ ;

Liu, JK .

LIPIDS, 2001, 36 (02) :175-180

[2]

HUA HM, 2000, CHINESE J MED CHEM, V10, P57

[3] Antiinflammatory and analgesic activities of the tissue culture of Saussurea involucrata [J].

Jia, JM ;

Wu, CF ;

Liu, W ;

Yu, H ;

Hao, Y ;

Zheng, JH ;

Ji, YR .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, 28 (09) :1612-1614

[4]

Jia Z., 1988, CHEM J CHINESE U, V9, P198

[5]

Jia Z.J., 1983, CHEM J CHINESE U, V4, P581

[6] OPHIDIACEREBROSIDES - CYTOTOXIC GLYCOSPHINGOLIPIDS CONTAINING A NOVEL SPHINGOSINE FROM A SEA STAR [J].

JIN, WZ ;

RINEHART, KL ;

JARESERIJMAN, EA .

JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (01) :144-147

[7] 2 FLAVANONES FROM THE ROOT BARK OF LESPEDEZA-DAVIDII [J].

LI, JR ;

WANG, MS .

PHYTOCHEMISTRY, 1989, 28 (12) :3564-3566

[8]

Li Y., 1985, CHEM J CHINESE U, V6, P417

[9]

[李燕 LI Yan], 2007, [中国药学杂志, Chinese Pharmaceutical Journal], V42, P575

[10] Three guaianolides from Saussurea involucrata and their contents determination by HPLC [J].

Li, Yan ;

Wang, Chunlan ;

Guo, Shunxing ;

Yang, Junshan ;

Xiao, Peigen .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2007, 44 (01) :288-292

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