Heritability of plasma amino acid levels in different nutritional states

被引：7
作者：
McBride, Kim L.
Belmont, John W.
O'Brien, William E.
Amin, Tanay J.
Carter, Susan
Lee, Brendan H.
机构：
[1] Ohio State Univ, Ctr Mol & Human Genet, Columbus Childrens Res Inst, Dept Pediat, Columbus, OH 43205 USA
[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
[3] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA
来源：
MOLECULAR GENETICS AND METABOLISM | 2007年 / 90卷 / 02期
关键词：
genetics; metabolism; inborn errors; amino acid metabolism; amino acids; diet; protein; heritable quantitative trait;
D O I：
10.1016/j.ymgme.2006.08.010
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Significant heritability has been shown for several plasma amino acid levels, but the results may have been confounded by sampling in a variety of nutritional states. We studied a group of families on a low protein steady-state diet in fasting and non-fasting states. Heritability of individual amino acids varied according to the nutritional state, suggesting the amount of genetic and environmental influences differ among the operative systems that control individual amino acid homeostasis throughout the feed/fast cycle. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：217 / 220
页数：4
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