Cardiac Amyloidosis: Updates in Imaging

被引：50

作者：

Chacko, Liza ^{[1
]}

Martone, Raffaele ^{[2
]}

Cappelli, Francesco ^{[2
]}

Fontana, Marianna ^{[1
]}

机构：

[1] UCL, Natl Amyloidosis Ctr, Royal Free Campus,Rowland Hill St, London NW3 2PF, England

[2] Careggi Univ Hosp, Tuscan Reg Amyloid Ctr, Florence, Italy

来源：

CURRENT CARDIOLOGY REPORTS | 2019年 / 21卷 / 09期

关键词：

Cardiac amyloidosis; Magnetic resonance imaging; Cardiomyopathy; Immunoglobulin light chain; Transthyretin; Echocardiography; CARDIOVASCULAR MAGNETIC-RESONANCE; LIGHT-CHAIN AMYLOIDOSIS; TRANSTHYRETIN AMYLOIDOSIS; NATURAL-HISTORY; SYSTEMIC AMYLOIDOSIS; AL AMYLOIDOSIS; DIAGNOSIS; HEREDITARY; GADOLINIUM; SCINTIGRAPHY;

D O I：

10.1007/s11886-019-1180-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of Review We summarize key features pertaining to the two most commonly encountered types of cardiac amyloidosis (CA), monoclonal immunoglobulin light chain (AL) and transthyretin type (ATTR), expanding upon the clinical application and utility of various imaging techniques in diagnosing CA. Recent Findings Advances in imaging have led to earlier identification, improved diagnosis of CA and higher discriminatory power to differentiate CA from other hypertrophic phenocopies. The application of cardiac magnetic resonance imaging (CMR) has led to a deeper understanding of underlying pathophysiological processes in CA, owing largely to its intrinsic tissue characterization properties. The widespread adoption of bone scintigraphy algorithms has reduced the need for cardiac biopsy and improved diagnostic confidence in ATTR CA. As new treatments for CA are rapidly developing, there will be even greater reliance on imaging, as the requirement to diagnose disease earlier, monitor response and amend treatment strategies accordingly intensifies.

引用

页数：9

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