Effects of growth hormone in patients with chronic renal failure:: Experience in children and adults

被引：18
作者：
Wühl, E [1 ]
Schaefer, F [1 ]
机构：
[1] Univ Heidelberg, Sekt Padiat Nephrol, Div Paediat Nephrol, D-69120 Heidelberg, Germany
来源：
HORMONE RESEARCH | 2002年 / 58卷
关键词：
growth hormone treatment; chronic renal failure; children; adults;
D O I：
10.1159/000066480
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recombinant human growth hormone (GH) has proven effective in promoting growth in short children with chronic renal failure before and after renal transplantation. The action of GH and its mediator insulin-like growth factor 1 on body composition, protein, glucose and bone metabolism offers additional therapeutic options. One might be the improvement of the catabolic state in adults with end-stage renal failure. In few pilot studies and two placebo-controlled studies of 6 months duration, GH treatment in adults on dialysis showed clear anabolic effects resulting in a significant increase in lean body mass. Copyright (C) 2002 S. Karger AG, Basel.
引用
收藏
页码：35 / 38
页数：4
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