Indication for a Single Postoperative Instillation of Chemotherapy in Non-muscle-invasive Bladder Cancer: What Factors Should Be Considered?

被引：6

作者：

Babjuk, Marko ^{[1
,2
]}

Burger, Maximilian ^{[5
]}

Comperat, Eva M. ^{[6
]}

Gontero, Paolo ^{[7
]}

Mostafid, Hugh A. ^{[8
]}

Palou, Joan ^{[9
]}

van Rhijn, Bas W. G. ^{[10
]}

Roupret, Morgan ^{[11
]}

Shariat, Shahrokh F. ^{[1
,2
,3
,4
]}

Sylvester, Richard ^{[12
]}

Zigeunerm, Richard ^{[13
]}

Capoun, Otakar ^{[14
]}

Cohen, Daniel ^{[15
,16
]}

Dominguez-Escrig, Jose L. ^{[17
]}

Hernandez, Virginia ^{[18
]}

Peyronnet, Benoit ^{[19
]}

Seisen, Thomas ^{[11
]}

Soukup, Viktor ^{[14
]}

机构：

[1] Charles Univ Prague, Hosp Motol, Fac Med 2, Dept Urol, Prague, Czech Republic

[2] Med Univ Vienna, Vienna Gen Hosp, Vienna, Austria

[3] Univ Texas Southwestern Med Ctr Dallas, Dept Urol, Dallas, TX 75390 USA

[4] Weill Cornell Med Coll, Dept Urol, New York, NY USA

[5] Univ Regensburg, Caritas St Josef Med Ctr, Dept Urol, Regensburg, Germany

[6] Sorbonne Univ, Hop Tenon, AP HP, Dept Pathol, Paris, France

[7] Univ Turin, San Giovanni Battista Hosp, Citta Salute & Sci, Dept Urol, Turin, Italy

[8] Royal Surrey Cty Hosp, Dept Urol, Guildford, Surrey, England

[9] Univ Autonoma Barcelona, Dept Urol, Fundacio Puigvert, Barcelona, Spain

[10] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Urol, Amsterdam, Netherlands

[11] Sorbonne Univ, Hop La Pitie Salpetriere, AP HP, Dept Urol, Paris, France

[12] European Assoc Urol, Guidelines Off, Brussels, Belgium

[13] Med Univ Graz, Dept Urol, Graz, Austria

[14] Charles Univ Prague, Gen Univ Hosp, Fac Med 1, Dept Urol, Prague, Czech Republic

[15] Imperial Coll London, Dept Surg & Canc, London, England

[16] Lister Hosp, East & North Hertfordshire NHS Trust, Dept Urol, Stevenage, Herts, England

[17] Fdn Inst Valenciano Oncol, Serv Urol, Valencia, Spain

[18] Hosp Univ Fdn Alcorcon, Dept Urol, Madrid, Spain

[19] CHU Rennes, Serv Urol, Rennes, France

来源：

EUROPEAN UROLOGY FOCUS | 2018年 / 4卷 / 04期

关键词：

Bladder cancer; Non-muscle-invasive; Single postoperative instillation of chemotherapy; Indication; INTRAVESICAL CHEMOTHERAPY; TRANSURETHRAL RESECTION; MITOMYCIN-C; RECURRENCE; TUMOR; IMPLANTATION; METAANALYSIS; INHIBITION; MANAGEMENT; CARCINOMA;

D O I：

10.1016/j.euf.2018.07.023

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

An early single instillation of intravesical chemotherapy (SICI) used immediately after transurethral resection of the bladder (TURB) can significantly reduce the recurrence rate in selected patients with non-muscle-invasive bladder cancer(NMIBC). SICI should be used in patients with low-risk and with selected intermediate-risk tumours, in particular for multiple primary small papillary tumours, single primary papillary tumours >3 cm, and single recurrent papillary tumours recurring >1 yr after the previous resection. The available data do not support any recommendation to reduce the role of SICI in patients after fluorescence cystoscopy-guided TURB oren bloc TURB. SICI can even provide some benefit inpatients with intermediate-risk tumours subsequently treated with further instillations. During instillation, contraindications should be taken into account and safety measures should be applied. Patient summary: An early single instillation of intravesical chemotherapy immediately after transurethral resection of the bladder can significantly reduce the recurrence rate in selected patients with non-muscle-invasive bladder cancer. It should be used in patients with low-risk and selected intermediate-risk tumours. (C) 2018 European Association of Urology. Published by Elsevier B.V. All rights reserved.

引用

页码：525 / 528

页数：4

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