共 96 条
Autoimmune myocarditis: Past, present and future
被引:68
作者:

Leuschner, Florian
论文数: 0 引用数: 0
h-index: 0
机构:
Heidelberg Univ, Dept Cardiol, D-69120 Heidelberg, Germany Heidelberg Univ, Dept Cardiol, D-69120 Heidelberg, Germany

Katus, Hugo A.
论文数: 0 引用数: 0
h-index: 0
机构:
Heidelberg Univ, Dept Cardiol, D-69120 Heidelberg, Germany Heidelberg Univ, Dept Cardiol, D-69120 Heidelberg, Germany

Kaya, Ziya
论文数: 0 引用数: 0
h-index: 0
机构:
Heidelberg Univ, Dept Cardiol, D-69120 Heidelberg, Germany Heidelberg Univ, Dept Cardiol, D-69120 Heidelberg, Germany
机构:
[1] Heidelberg Univ, Dept Cardiol, D-69120 Heidelberg, Germany
关键词:
Autoimmunity;
Myocarditis;
Mouse models;
Cardiac myosin;
Cardiac troponins;
Cytokines;
Chemokines;
CARDIAC TROPONIN-I;
SUBSEQUENT IMMUNOGLOBULIN SUBSTITUTION;
COXSACKIEVIRUS B3-INDUCED MYOCARDITIS;
MONOCYTE CHEMOATTRACTANT PROTEIN-1;
CONVERTING ENZYME-INHIBITION;
LEFT-VENTRICULAR DYSFUNCTION;
AMERICAN-HEART-ASSOCIATION;
IMPAIRED UP-REGULATION;
TOLL-LIKE RECEPTOR-3;
DILATED CARDIOMYOPATHY;
D O I:
10.1016/j.jaut.2009.07.009
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Heart failure has become an increasingly prevalent disorder with considerable morbidity and mortality. While many causal mechanisms such as inherited cardiomyopathies, ischemic cardiomyopathy or muscular overload are easily identified in clinical practice, the molecular mechanisms that determine the progression of heart failure or ventricular remodelling are largely unknown. Autoimmune responses and inflammation are involved in the pathogenesis of many cardiovascular diseases. There is compelling evidence that inflammatory mechanisms may contribute to progressive heart failure. Thus, myocardial infiltration of lymphocytes and mononuclear cells, increased expression of pro-inflammatory chemokines and cytokines and circulating autoantibodies are frequently observed in myocarditis and dilated cardiomyopathy. In this review we give an overview on myocarditis and describe why diagnosis and treatment of myocarditis in the clinic can be difficult. We present current animal models and describe possible experimental approaches to improve diagnosis. Finally, we give an outlook on possible drug targets by describing the latest findings in the animal models focussing on chemokines and cytokines, T cell responses and interactions, tolerance induction and the development of autoantibodies. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:282 / 289
页数:8
相关论文
共 96 条
[1]
Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis -: Comparison of different approaches
[J].
Abdel-Aty, H
;
Boyé, P
;
Zagrosek, A
;
Wassmuth, R
;
Kumar, A
;
Messroghli, D
;
Bock, P
;
Dietz, R
;
Friedrich, MG
;
Schulz-Menger, J
.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,
2005, 45 (11)
:1815-1822

Abdel-Aty, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Berlin, Franz Volhard Klin, Berlin, Germany

Boyé, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Berlin, Franz Volhard Klin, Berlin, Germany

Zagrosek, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Berlin, Franz Volhard Klin, Berlin, Germany

Wassmuth, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Berlin, Franz Volhard Klin, Berlin, Germany

Kumar, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Berlin, Franz Volhard Klin, Berlin, Germany

Messroghli, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Berlin, Franz Volhard Klin, Berlin, Germany

Bock, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Berlin, Franz Volhard Klin, Berlin, Germany

Dietz, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Berlin, Franz Volhard Klin, Berlin, Germany

Friedrich, MG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Berlin, Franz Volhard Klin, Berlin, Germany

Schulz-Menger, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Berlin, Franz Volhard Klin, Berlin, Germany
[2]
Impaired up-regulation of CD25 on CD4+ T cells in IFN-γ knockout mice is associated with progression of myocarditis to heart failure
[J].
Afanasyeva, M
;
Georgakopoulos, D
;
Belardi, DF
;
Bedja, D
;
Fairweather, D
;
Wang, Y
;
Kaya, Z
;
Gabrielson, KL
;
Rodriguez, ER
;
Caturegli, P
;
Kass, DA
;
Rose, NR
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2005, 102 (01)
:180-185

Afanasyeva, M
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Georgakopoulos, D
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Belardi, DF
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Bedja, D
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Fairweather, D
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Wang, Y
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Kaya, Z
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Gabrielson, KL
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Rodriguez, ER
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Caturegli, P
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Kass, DA
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Rose, NR
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA
[3]
Quantitative analysis of myocardial inflammation by flow cytometry in murine autoimmune myocarditis - Correlation with cardiac function
[J].
Afanasyeva, M
;
Georgakopoulos, D
;
Belardi, DF
;
Ramsundar, AC
;
Barin, JG
;
Kass, DA
;
Rose, NR
.
AMERICAN JOURNAL OF PATHOLOGY,
2004, 164 (03)
:807-815

Afanasyeva, M
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Georgakopoulos, D
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Belardi, DF
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Ramsundar, AC
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Barin, JG
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Kass, DA
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Rose, NR
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA
[4]
Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-γ-independent pathway
[J].
Afanasyeva, M
;
Wang, Y
;
Kaya, Z
;
Stafford, EA
;
Dohmen, KM
;
Akha, AAS
;
Rose, NR
.
CIRCULATION,
2001, 104 (25)
:3145-3151

Afanasyeva, M
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Wang, Y
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Kaya, Z
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Stafford, EA
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Dohmen, KM
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Akha, AAS
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Rose, NR
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA
[5]
Experimental autoimmune myocarditis in A/J mice is an interleukin-4-dependent disease with a Th2 phenotype
[J].
Afanasyeva, M
;
Wang, Y
;
Kaya, Z
;
Park, S
;
Zilliox, MJ
;
Schofield, BH
;
Hill, SL
;
Rose, NR
.
AMERICAN JOURNAL OF PATHOLOGY,
2001, 159 (01)
:193-203

Afanasyeva, M
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Wang, Y
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Kaya, Z
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Park, S
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Zilliox, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Schofield, BH
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Hill, SL
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

Rose, NR
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA
[6]
Low-molecular-weight tumor necrosis factor receptor p55 controls induction of autoimmune heart disease
[J].
Bachmaier, K
;
Pummerer, C
;
Kozieradzki, I
;
Pfeffer, K
;
Mak, TW
;
Neu, N
;
Penninger, JM
.
CIRCULATION,
1997, 95 (03)
:655-661

Bachmaier, K
论文数: 0 引用数: 0
h-index: 0
机构: UNIV TORONTO, DEPT MED BIOPHYS, AMGEN INST, ONTARIO CANC INST, TORONTO, ON M5G 2C1, CANADA

Pummerer, C
论文数: 0 引用数: 0
h-index: 0
机构: UNIV TORONTO, DEPT MED BIOPHYS, AMGEN INST, ONTARIO CANC INST, TORONTO, ON M5G 2C1, CANADA

Kozieradzki, I
论文数: 0 引用数: 0
h-index: 0
机构: UNIV TORONTO, DEPT MED BIOPHYS, AMGEN INST, ONTARIO CANC INST, TORONTO, ON M5G 2C1, CANADA

Pfeffer, K
论文数: 0 引用数: 0
h-index: 0
机构: UNIV TORONTO, DEPT MED BIOPHYS, AMGEN INST, ONTARIO CANC INST, TORONTO, ON M5G 2C1, CANADA

Mak, TW
论文数: 0 引用数: 0
h-index: 0
机构: UNIV TORONTO, DEPT MED BIOPHYS, AMGEN INST, ONTARIO CANC INST, TORONTO, ON M5G 2C1, CANADA

Neu, N
论文数: 0 引用数: 0
h-index: 0
机构: UNIV TORONTO, DEPT MED BIOPHYS, AMGEN INST, ONTARIO CANC INST, TORONTO, ON M5G 2C1, CANADA

Penninger, JM
论文数: 0 引用数: 0
h-index: 0
机构: UNIV TORONTO, DEPT MED BIOPHYS, AMGEN INST, ONTARIO CANC INST, TORONTO, ON M5G 2C1, CANADA
[7]
Comparison of angiotensin converting enzyme inhibition and angiotensin II receptor blockade for the prevention of experimental autoimmune myocarditis
[J].
Bahk, Thomas J.
;
Daniels, Melvin D.
;
Leon, Juan S.
;
Wang, Kegiang
;
Engman, David A.
.
INTERNATIONAL JOURNAL OF CARDIOLOGY,
2008, 125 (01)
:85-93

Bahk, Thomas J.
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Dept Immunol Microbiol, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Feinberg Cardiovasc Res Inst, Chicago, IL 60611 USA Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA

Daniels, Melvin D.
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Dept Immunol Microbiol, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Feinberg Cardiovasc Res Inst, Chicago, IL 60611 USA Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA

Leon, Juan S.
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Dept Immunol Microbiol, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Feinberg Cardiovasc Res Inst, Chicago, IL 60611 USA Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA

Wang, Kegiang
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Dept Immunol Microbiol, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Feinberg Cardiovasc Res Inst, Chicago, IL 60611 USA Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA

Engman, David A.
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Dept Immunol Microbiol, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Feinberg Cardiovasc Res Inst, Chicago, IL 60611 USA Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA
[8]
Autoimmunity: From the mosaic to the kaleidoscope
[J].
Blank, Miri
;
Gershwin, M. Eric
.
JOURNAL OF AUTOIMMUNITY,
2008, 30 (1-2)
:1-4

Blank, Miri
论文数: 0 引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Ctr Autoimmune Dis, Tel Hashomer, Israel
Tel Aviv Univ, Dept Med B, Chaim Sheba Med Ctr, Tel Hashomer, Israel Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA

Gershwin, M. Eric
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA
[9]
Dual role of CCR2 during initiation and progression of collagen-induced arthritis:: Evidence for regulatory activity of CCR2+ T cells
[J].
Brühl, H
;
Cihak, J
;
Schneider, MA
;
Plachy, J
;
Rupp, T
;
Wenzel, I
;
Shakarami, M
;
Milz, S
;
Ellwart, JW
;
Stangassinger, M
;
Schlöndorff, D
;
Mack, M
.
JOURNAL OF IMMUNOLOGY,
2004, 172 (02)
:890-898

Brühl, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Poliklin, D-80336 Munich, Germany

Cihak, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Poliklin, D-80336 Munich, Germany

Schneider, MA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Poliklin, D-80336 Munich, Germany

Plachy, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Poliklin, D-80336 Munich, Germany

Rupp, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Poliklin, D-80336 Munich, Germany

Wenzel, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Poliklin, D-80336 Munich, Germany

Shakarami, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Poliklin, D-80336 Munich, Germany

Milz, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Poliklin, D-80336 Munich, Germany

Ellwart, JW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Poliklin, D-80336 Munich, Germany

Stangassinger, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Poliklin, D-80336 Munich, Germany

Schlöndorff, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Poliklin, D-80336 Munich, Germany

Mack, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Med Poliklin, D-80336 Munich, Germany
[10]
Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-α
[J].
Bryant, D
;
Becker, L
;
Richardson, J
;
Shelton, J
;
Franco, F
;
Peshock, R
;
Thompson, M
;
Giroir, B
.
CIRCULATION,
1998, 97 (14)
:1375-1381

Bryant, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX 75235 USA

Becker, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX 75235 USA

Richardson, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX 75235 USA

Shelton, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX 75235 USA

Franco, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX 75235 USA

Peshock, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX 75235 USA

Thompson, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX 75235 USA

Giroir, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX 75235 USA