Asymmetries of Dark and Bright Negative Afterimages Are Paralleled by Subcortical ON and OFF Poststimulus Responses

被引:13
作者
Li, Hui [1 ,2 ]
Liu, Xu [1 ,2 ]
Andolina, Ian M. [1 ]
Li, Xiaohong [1 ]
Lu, Yiliang [1 ]
Spillmann, Lothar [3 ]
Wang, Wei [1 ]
机构
[1] Chinese Acad Sci, Inst Neurosci, State Key Lab Neurosci, Key Lab Primate Neurobiol,Ctr Excellence Brain Sc, Shanghai 200031, Peoples R China
[2] Univ Chinese Acad Sci, Shanghai 200031, Peoples R China
[3] Univ Freiburg, Dept Neurol, D-79085 Freiburg, Germany
基金
中国国家自然科学基金;
关键词
afterimage; asymmetry; LGN; OFF; ON; LATERAL GENICULATE-NUCLEUS; RETINAL GANGLION-CELLS; PRIMARY VISUAL-CORTEX; SPATIAL SUMMATION; TEMPORAL CONTRAST; MAMMALIAN RETINA; TURTLE RETINA; CATS RETINA; X-CELLS; Y-CELLS;
D O I
10.1523/JNEUROSCI.2021-16.2017
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Humans are more sensitive to luminance decrements than increments, as evidenced by lower thresholds and shorter latencies for dark stimuli. This asymmetry is consistent with results of neurophysiological recordings in dorsal lateral geniculate nucleus (dLGN) and primary visual cortex (V1) of cat and monkey. Specifically, V1 population responses demonstrate that darks elicit higher levels of activation than brights, and the latency of OFF responses in dLGN and V1 is shorter than that of ON responses. The removal of a dark or bright disc often generates the perception of a negative afterimage, and here we ask whether there also exist asymmetries for negative afterimages elicited by dark and bright discs. If so, do the poststimulus responses of subcortical ON and OFF cells parallel such afterimage asymmetries? To test these hypotheses, we performed psychophysical experiments in humans and single-cell/S-potential recordings in cat dLGN. Psychophysically, we found that bright afterimages elicited by luminance decrements are stronger and last longer than dark afterimages elicited by luminance increments of equal sizes. Neurophysiologically, we found that ON cells responded to the removal of a dark disc with higher firing rates that were maintained for longer than OFF cells to the removal of a bright disc. The ON and OFF cell asymmetry was most pronounced at long stimulus durations in the dLGN. We conclude that subcortical response strength differences between ON and OFF channels parallel the asymmetries between bright and dark negative afterimages, further supporting a subcortical origin of bright and dark afterimage perception.
引用
收藏
页码:1984 / 1996
页数:13
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