Preconception folic acid supplementation use and the occurrence of neural tube defects in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study

被引：11

作者：

Nishigori, Hidekazu ^{[1
,2
]}

Obara, Taku ^{[2
,3
,4
]}

Nishigori, Toshie ^{[1
]}

Ishikuro, Mami ^{[4
]}

Sakurai, Kasumi ^{[2
]}

Hoshiai, Tetsuro ^{[1
]}

Saito, Masatoshi ^{[1
]}

Fujiwara, Ikuma ^{[2
]}

Arima, Takahiro ^{[2
]}

Nakai, Kunihiko ^{[2
]}

Kuriyanna, Shinichi ^{[2
,4
,5
]}

Mano, Nariyasu ^{[3
]}

Metoki, Hirohito ^{[6
]}

Yaegashi, Nobuo ^{[1
,2
,9
]}

Kawamoto, Toshihiro ^{[7
]}

Saito, Hirohisa ^{[7
]}

Kishi, Reiko ^{[8
]}

Hashimoto, Koichi ^{[10
]}

Mori, Chisato ^{[11
]}

Ito, Shuichi ^{[12
]}

Yamagata, Zentaro ^{[13
]}

Inadera, Hidekuni ^{[14
]}

Kamijima, Michihiro ^{[15
]}

Nakayama, Takeo ^{[16
]}

Iso, Hiroyasu ^{[17
]}

Shima, Masayuki ^{[18
]}

Hirooka, Yasuaki ^{[19
]}

Suganuma, Narufumi ^{[20
]}

Kusuhara, Koichi ^{[21
]}

Katoh, Takahiko ^{[22
]}

机构：

[1] Tohoku Univ, Dept Obstet & Gynecol, Grad Sch Med, Sendai, Miyagi, Japan

[2] Tohoku Univ, Environm & Genome Res Ctr, Grad Sch Med, Sendai, Miyagi, Japan

[3] Tohoku Univ Hosp, Dept Pharmaceut Sci, Sendai, Miyagi, Japan

[4] Tohoku Univ, Tohoku Med Megabank Org, Sendai, Miyagi, Japan

[5] Tohoku Univ, Int Res Inst Disaster Sci, Sendai, Miyagi, Japan

[6] Tohoku Med & Pharmaceut Univ, Fac Med, Div Publ Hlth Hyg & Epidemiol, Sendai, Miyagi, Japan

[7] Natl Ctr Child Hlth & Dev, Tokyo, Japan

[8] Hokkaido Univ, Sapporo, Hokkaido, Japan

[9] Tohoku Univ, Sendai, Miyagi, Japan

[10] Fukushima Med Univ, Fukushima, Japan

[11] Chiba Univ, Chiba, Japan

[12] Yokohama City Univ, Yokohama, Kanagawa, Japan

[13] Univ Yamanashi, Chuo, Japan

[14] Univ Toyama, Toyama, Japan

[15] Nagoya City Univ, Nagoya, Aichi, Japan

[16] Kyoto Univ, Kyoto, Japan

[17] Osaka Univ, Suita, Osaka, Japan

[18] Hyogo Coll Med, Nishinomiya, Hyogo, Japan

[19] Tottori Univ, Yonago, Tottori, Japan

[20] Kochi Univ, Nankoku, Kochi, Japan

[21] Univ Occupat & Environm Hlth, Kitakyushu, Fukuoka, Japan

[22] Kumamoto Univ, Kumamoto, Japan

来源：

CONGENITAL ANOMALIES | 2019年 / 59卷 / 04期

关键词：

folic acid supplementation; Japan; neural tube defect; RISK-FACTORS; PREVENTION; PREVALENCE; WOMEN;

D O I：

10.1111/cga.12293

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We evaluated the relationship between preconception folic acid supplementation and the occurrence of neural tube defects (NTDs) in offspring, using data from the Japan Environment and Children's Study (a nationwide prospective birth cohort study) database. Of 92 269 participants with single pregnancies, 74 cases (offspring or fetuses) had NTDs, including 32 cases of spina bifida, 24 cases of anencephaly, and 19 cases of encephalocele. A total of 7634 participants (8.27%) used preconception folic acid supplementation, and of these, 621 (0.67%) also took in dietary folic acid at >= 480 mu g/day. Multivariate logistic regression analyses demonstrated no association between preconception folic acid supplementation and NTDs in offspring or fetuses (odds ratio [OR] 0.622; 95% confidence interval [CI]: 0.226-1.713). Moreover, the participants who combined preconception folic acid supplement use with dietary folic acid intake >= 480 mu g/day demonstrated no incidence of NTDs in offspring or fetuses. Our analysis is limited by the absence of the data on the daily amount of supplementary folic acid intake, requiring careful attention to the interpretation. Additional surveys are required in Japan to resolve those limitations for further comprehensive assessment.

引用

页码：110 / 117

页数：8

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