Biosynthesis of alkyne-containing natural products

被引：38
|
作者：
Li, Xinyang [1 ]
Lv, Jian-Ming [2 ]
Hu, Dan [2 ]
Abe, Ikuro [1 ,3 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan
[2] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Peoples R China
[3] Univ Tokyo, Collaborat Res Inst Innovat Microbiol, Bunkyo Ku, Yayoi 1-1-1, Tokyo 1138657, Japan
来源：
RSC CHEMICAL BIOLOGY | 2021年 / 2卷 / 01期
基金：
日本科学技术振兴机构;
关键词：
FATTY-ACID SYNTHESIS; GENE-CLUSTER; POLYKETIDE SYNTHASE; ACYLTRANSFERASE DOMAIN; DYNEMICIN ENEDIYNE; COA DESATURASE; TRIPLE BOND; ENZYME; CHEMISTRY; MECHANISM;
D O I：
10.1039/d0cb00190b
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alkyne-containing natural products are important molecules that are widely distributed in microbes and plants. Inspired by the advantages of acetylenic products used in the fields of medicinal chemistry, organic synthesis and material science, great efforts have focused on discovering the biosynthetic enzymes and pathways for alkyne formation. Here, we summarize the biosyntheses of alkyne-containing natural products and introduce de novo biosynthetic strategies for alkyne-tagged compound production.
引用
收藏
页码：166 / 180
页数：15
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