Characterization of the novel focal adhesion kinase RAFTK in hematopoietic cells

被引：25

作者：

Avraham, S ^{[1
]}

Avraham, H ^{[1
]}

机构：

[1] HARVARD UNIV,INST MED,BIDMC,DIV EXPT MED,BOSTON,MA 02115

来源：

LEUKEMIA & LYMPHOMA | 1997年 / 27卷 / 3-4期

关键词：

novel focal adhesion kinase; RAFTK; hematopoietic cells;

D O I：

10.3109/10428199709059681

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Protein tyrosine kinases (PTKs) mediate signals that respond to many pivotal cellular functions. Tyrosine phosphorylation, controlled by the coordinated actions of protein tyrosine phosphatases (PTPs) and PTKs, is a critical control mechanism for various physiological processes, including cell growth, differentiation, metabolism, cell cycle regulation and cytoskeleton function. The focal adhesion kinase (FAK) is a widely expressed non-receptor tyrosine kinase that is implicated in integrin-mediated signaling and plays a role in signal transduction pathways mediating cell adhesion, motility and anchorage-independent growth. Recently, we and others have identified a novel protein tyrosine kinase termed RAFTK, (also known as Pyk2 or Cak-beta), which is related to FAK. This review describes the role of RAFTK in various signaling cascades mainly in reference to hematopoietic cell lineages.

引用

页码：247 / 256

页数：10

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