Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis

被引：12

作者：

Imai, Ayano ^{[1
]}

Takase, Hiroshi ^{[1
]}

Imadome, Ken-Ichi ^{[2
]}

Matsuda, Go ^{[2
]}

Ohnishi, Iichiro ^{[3
]}

Yamamoto, Kouhei ^{[3
]}

Kudo, Takumi ^{[4
]}

Tanaka, Yoji ^{[4
]}

Maehara, Taketoshi ^{[4
]}

Miura, Osamu ^{[5
]}

Arai, Ayako ^{[5
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Ophthalmol, Tokyo, Japan

[2] Natl Res Inst Child Hlth & Dev, Div Adv Med Virus Infect, Tokyo, Japan

[3] Tokyo Med & Dent Univ, Dept Comprehens Pathol, Tokyo, Japan

[4] Tokyo Med & Dent Univ, Dept Funct Neurosurg, Tokyo, Japan

[5] Tokyo Med & Dent Univ, Dept Hematol, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2017年 / 56卷 / 11期

关键词：

extranodal NK/T-cell lymphoma nasal type; central nervous system; uveitis; Epstein-Barr virus; INFECTION; DISEASE; BRAIN;

D O I：

10.2169/internalmedicine.56.7573

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 74-year-old woman developed bilateral uveitis with high Epstein-Barr virus (EBV) DNA load in the vitreous fluid without lymphoma cells. Four years after the onset, T2-weighted contrast-enhanced MRI revealed hyperintense lesions in the right occipital and parietal lobe. A biopsy resulted in the diagnosis of extranodal NK/T-cell lymphoma nasal type (ENKL). The repeat region of LMP1, an EBV gene, detected in the brain lesion was identical to that detected in the vitreous fluid. ENKL of the central nervous system is quite rare, and the pathogenesis has not been determined. The lymphoma in this case might have been closely associated with the EBV-positive uveitis.

引用

页码：1409 / 1414

页数：6

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