Association of blood levels of C-reactive protein with clinical phenotypes in Arab schizophrenic patients

被引:53
作者
Akanji, Abayomi O. [1 ]
Ohaeri, Jude U. [2 ]
Al-Shammri, Suhail [3 ]
Fatania, Hasmukh R. [4 ]
机构
[1] Kuwait Univ, Clin Chem Unit, Dept Pathol, Fac Med, Safat 13110, Kuwait
[2] Psychol Med Hosp, Sulibikhat, Kuwait
[3] Kuwait Univ, Dept Med, Fac Med, Safat 13110, Kuwait
[4] Kuwait Univ, Dept Biochem, Fac Med, Safat 13110, Kuwait
关键词
Arabs; Schizophrenia; CRP; Cytokines; Disease phenotypes; Metabolic syndrome; ELEVATED SERUM-LEVELS; CARDIOVASCULAR-DISEASE; RISK; INFLAMMATION; SYMPTOMS; INTERLEUKIN-6; HOMOCYSTEINE; PREDICTORS; DEPRESSION; COHORT;
D O I
10.1016/j.psychres.2008.06.010
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Schizophrenia may be associated with inflammatory reactions and C-reactive protein (CRP) is a nonspecific serum protein marker for persisting inflammatory states. This study aimed to assess concentrations of high sensitivity CRP (hsCRP) in schizophrenic Arab patients and evaluate the relationships of hsCRP levels with aspects of clinical phenotypes of the disease. Two age-matched groups of subjects were studied: (1) healthy controls, HC, n = 165; (2) patients with schizophrenia, SZ: n = 207. Each subject was evaluated with a standard questionnaire for age at disease onset, family history, disease severity and outcome. Serum hsCRP levels were measured by immunoassay. The two groups of subjects were similar in age, ethnic composition and socioeconomic status. Those with SZ had significantly greater serum concentrations of hsCRP. There were significant associations between hsCRP and (i) age in both groups: (ii) body mass index (BMI) in HC but not in SZ. In the latter, hsCRP levels were: (a) marginally higher in women with later age of disease onset; (ii) highest with remission and with catatonic features: and (iii) lower with family history of psychosis. The study concludes that serum levels of hsCRP are increased in clinically stable Arab patients with schizophrenia and appear related to the disorder's clinical expression. It is suggested that there may be an inflammatory component to schizophrenia which is associated with aspects of its clinical phenotype. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:56 / 61
页数:6
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