Sex-Dependent Effects of HO-1 Deletion from Adipocytes in Mice

被引：16

作者：

Hosick, Peter A. ^{[1
,2
]}

Weeks, Mary Frances ^{[1
]}

Hankins, Michael W. ^{[1
]}

Moore, Kyle H. ^{[1
]}

Stec, David E. ^{[1
]}

机构：

[1] Univ Mississippi, Dept Physiol & Biophys, Ctr Excellence Cardiovasc Renal Res, Med Ctr, 2500 North State St, Jackson, MS 39216 USA

[2] Montclair State Univ, Dept Exercise Sci & Phys Educ, Montclair, NJ 07043 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 03期

关键词：

obesity; diabetes; bilirubin; Cre recombinase; insulin resistance; adiponectin; IMPROVES INSULIN SENSITIVITY; INCREASES ADIPONECTIN LEVELS; HEME OXYGENASE INDUCER; FATTY LIVER-DISEASE; COBALT PROTOPORPHYRIN; GLUCOSE-METABOLISM; INDUCTION; OBESE; INFLAMMATION; SYSTEM;

D O I：

10.3390/ijms18030611

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Induction of heme oxygenase-1 (HO-1) has been demonstrated to decrease body weight and improve insulin sensitivity in several models of obesity in rodents. To further study the role of HO-1 in adipose tissue, we created an adipose-specific HO-1 knockout mouse model. Male and female mice were fed either a control or a high-fat diet for 30 weeks. Body weights were measured weekly and body composition, fasting blood glucose and insulin levels were determined every six weeks. Adipocyte-specific knockout of HO-1 had no significant effect on body weight in mice fed a high-fat diet but increased body weight in female mice fed a normal-fat diet. Although body weights were not different in females fed a high fat diet, loss of HO-1 in adipocytes resulted in significant alterations in body composition. Adipose-specific HO-1 knockout resulted in increased fasting hyperglycemia and insulinemia in female but not male mice on both diets. Adipose-specific knockout of HO-1 resulted in a significant loss of HO activity and a decrease in the protein levels of adiponectin in adipose tissue. These results demonstrate that loss of HO-1 in adipocytes has greater effects on body fat and fasting hyperglycemia in a sex-dependent fashion and that expression of HO-1 in adipose tissue may have a greater protective role in females as compared to males.

引用

页数：12

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