PHYSICAL EXERCISE IN RATS WITH EPILEPSY IS PROTECTIVE AGAINST SEIZURES Evidence of animal studies

被引：23

作者：

Arida, Ricardo Mario ^{[1
]}

Scorza, Fulvio Alexandre ^{[2
]}

Terra, Vera Cristina ^{[3
]}

Cysneiros, Roberta Monterazzo ^{[4
]}

Cavalheiro, Esper Abrao ^{[2
]}

机构：

[1] UNIFESP EPM, Dept Fisiol, Sao Paulo, Brazil

[2] UNIFESP EPM, Disciplina Neurol Expt, Sao Paulo, Brazil

[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Neurol Psiquiatria & Psicol Med, Ctr Cirurgia Epilepsia CIREP, Ribeirao Preto, SP, Brazil

[4] Univ Presbiteriana Mackenzie, Programa Posgrad Disturbios Desenvolvimento, Ctr Ciencias Biol & Saude, Sao Paulo, Brazil

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2009年 / 67卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

exercise; physical training; epilepsy; seizure; rat; SUDDEN UNEXPECTED DEATH; RISK-FACTORS; PILOCARPINE; ADULTS; MODEL;

D O I：

10.1590/S0004-282X2009000600010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

People with epilepsy have been discouraged from participating in physical activity due to the fear that it will exacerbate seizures. Clinical and animal studies indicate a reduction of seizure frequency as well as decrease susceptibility to subsequently evoked seizures after an exercise program. Analyses from experimental studies of animals with epilepsy submitted to physical training programs were performed. in all studies the physical training was able to reduce the number of spontaneous seizures in rats with epilepsy. Seizure occurrence during exercise was relatively absent in the majority of studies. No death was found in animals with epilepsy during 1680 h of exercise. Based on these results it is plausible encouraging persons with epilepsy to non-pharmacological treatments and preventative measures such as physical exercise.

引用

页码：1013 / 1016

页数：4

共 30 条

[1] Effects of different types of physical exercise on the staining of parvalbumin-positive neurons in the hippocampal formation of rats with epilepsy [J].