A new organocatalyst for 1,3-dipolar cycloadditions of nitrones to α,β-unsaturated aldehydes

被引：83

作者：

Chow, San San ^{[1
]}

Nevalainen, Marta ^{[1
]}

Evans, Catherine A. ^{[1
]}

Johannes, Charles W. ^{[1
]}

机构：

[1] Infin Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 02期

关键词：

enantioselectivity; 3+2] cycloadditions; organocatalysis; nitrones; isoxazolidines; diphenyl-prolinol; asymmetric catalysis;

D O I：

10.1016/j.tetlet.2006.11.029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The triflate salt resulting from the treatment of diphenyl-S-prolinol with trimethylsilyl triflate, catalyzes the addition of nitrones to alpha,beta-unsaturated aldehydes to provide isoxazolidines in high yields and excellent diastereo- and enantioselectivities. (c) 2006 Elsevier Ltd. All rights reserved.

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页码：277 / 280

页数：4

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