Opioids potentiate transmitter release from SK-N-SH human neuroblastoma cells by modulating N-type calcium channels

被引：15
作者：
Keren, O
Gafni, M
Sarne, Y
机构：
[1] Dept. of Physiology and Pharmacology, Mauerberger Chair Neuropharmacology, Tel-Aviv University
来源：
BRAIN RESEARCH | 1997年 / 764卷 / 1-2期
关键词：
opioid receptor; transmitter release; calcium channel; dopamine; neuroblastoma; pertussis toxin;
D O I：
10.1016/S0006-8993(97)00599-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Opioids induce dual (inhibitory and excitatory) regulation of depolarization-evoked [H-3]dopamine release in SK-N-SH cells through either mu or delta receptors. The potentiation of dopamine release by opioid agonists is mediated by N-type voltage-dependent calcium channels and does not involve G(i)/G(o) proteins. Removal of the excitatory opioid effect by blockade with omega-conotoxin, an N-channel antagonist, reveals the inhibitiory effect of opioids on release, thus suggesting that both modulatory effects of opioids are exerted in parallel. (C) 1997 Elsevier Science B.V.
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页码：277 / 282
页数：6
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