A Case Control Study on Serum Levels of Potential Biomarkers in Male Breast Cancer Patients

被引：6

作者：

Ahmed Abdelsalam, Kamal Eldin ^{[1
,2
]}

Asad, Mohammed ^{[1
]}

Ahmed, Monjid Ahmed Ibrahim ^{[1
,3
]}

Asdaq, Syed Mohammed Basheeruddin ^{[4
]}

Mohzari, Yahya ^{[5
]}

Alrashed, Ahmed ^{[6
]}

Alghamdi, NajwaJilan ^{[7
]}

Alrami, Kholoud Nasser ^{[8
]}

Alharbi, Wael Ahmed ^{[8
]}

机构：

[1] Shaqra Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Shaqra 11911, Saudi Arabia

[2] Omdurman Islamic Univ, Coll Med Lab Sci, Omdurman 825109, Sudan

[3] Al Neelain Univ, Fac Sci & Technol, Khartoum 11121, Sudan

[4] AlMaarefa Univ, Coll Pharm, Dept Pharm Practice, Riyadh 13713, Saudi Arabia

[5] King Saud Med City, Dept Clin Pharm, Riyadh 12746, Saudi Arabia

[6] KFMC, Main Hosp, Inpatient Dept, Pharmaceut Serv Adm, Riyadh 11564, Saudi Arabia

[7] Adham Gen Hosp, Dept Pharm, Adham 28653, Saudi Arabia

[8] King Fahad Med City, Pharmaceut Serv Dept, Riyadh 11564, Saudi Arabia

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2021年 / 18卷 / 09期

关键词：

dopamine; epinephrine; GABA; ghrelin; melatonin; serotonin; MELATONIN; DOPAMINE; GHRELIN; ESTROGEN; ANXIETY; ROLES; GABA;

D O I：

10.3390/ijerph18094852

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The global incidence of breast cancer among men is steadily growing. Despite this, compared to female breast cancer patients, there are very few studies on biomarkers in male breast cancer patients. A cross-sectional case control study was carried out to determine the serum levels of melatonin, ghrelin, dopamine, serotonin, epinephrine, and GABA in male breast cancer. All the recruited patients were obese, old, and had recently been diagnosed with the disease. They had not received any treatment for the cancer until the time of the study. Melatonin and epinephrine serum levels were significantly higher in breast cancer patients compared to their age-matched controls, whereas ghrelin, dopamine, GABA, and serotonin serum levels were lower in patients compared to the control group. The serum levels of most of the studied biomarkers in male breast cancer patients were similar to those observed in female breast cancer patients, except for serum melatonin levels.

引用

页数：9

共 34 条

[1]

Abdelwahab Yousef A.J, 2017, SEMIN ONCOL

[2] Screening, Assessment, and Care of Anxiety and Depressive Symptoms in Adults With Cancer: An American Society of Clinical Oncology Guideline Adaptation [J].

Andersen, Barbara L. ;

DeRubeis, Robert J. ;

Berman, Barry S. ;

Gruman, Jessie ;

Champion, Victoria L. ;

Massie, Mary Jane ;

Holland, Jimmie C. ;

Partridge, Ann H. ;

Bak, Kate ;

Somerfield, Mark R. ;

Rowland, Julia H. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15) :1605-U118

[3] Ghrelin and Breast Cancer: emerging Roles in Obesity, estrogen Regulation, and Cancer [J].

Au, CheukMan Cherie ;

Furness, John B. ;

Brown, Kristy A. .

FRONTIERS IN ONCOLOGY, 2017, 6

[4] Dopamine receptors - IUPHAR Review 13 [J].

Beaulieu, Jean-Martin ;

Espinoza, Stefano ;

Gainetdinov, Raul R. .

BRITISH JOURNAL OF PHARMACOLOGY, 2015, 172 (01) :1-23

[5] What does dopamine mean? [J].

Berke, Joshua D. .

NATURE NEUROSCIENCE, 2018, 21 (06) :787-793

[6] Melatonin and its ubiquitous anticancer effects [J].

Bhattacharya, Sankha ;

Patel, Krishna Kumar ;

Dehari, Deepa ;

Agrawal, Ashish Kumar ;

Singh, Sanjay .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2019, 462 (1-2) :133-155

[7] γ-amino butyric acid (GABA) level as an overall survival risk factor in breast cancer [J].

Brzozowska, Anna ;

Burdan, Franciszek ;

Duma, Dariusz ;

Solski, Janusz ;

Mazurkiewicz, Maria .

ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE, 2017, 24 (03) :435-439

[8] Melatonin: Physiological effects in humans [J].

Claustrat, B. ;

Leston, J. .

NEUROCHIRURGIE, 2015, 61 (2-3) :77-84

[9] Influence of Age on the Clinical Outcome of Breast Cancer for Men and the Development of Second Primary Cancers [J].

Cronin, Patricia A. ;

Romanoff, Anya ;

Zabor, Emily C. ;

Stempel, Michelle ;

Eaton, Anne ;

Smyth, Lillian M. ;

Ho, Alice Y. ;

Morrow, Monica ;

El-Tamer, Mahmoud ;

Gemignani, Mary L. .

ANNALS OF SURGICAL ONCOLOGY, 2018, 25 (13) :3858-3866

[10] An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid [J].

Dai-Hung Ngo ;

Thanh Sang Vo .

MOLECULES, 2019, 24 (15)

← 1 2 3 4 →