Immune Memory: the Basics and How to Trigger an Efficient Long-Term Immune Memory

被引：3

作者：

Beverley, P. C. L. ^{[1
]}

机构：

[1] Univ Oxford, Oxford OX1 3SY, England

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2010年 / 141卷

关键词：

kinetics; memory; protection; B-CELL SUBSETS; T-CELLS; RAPID TURNOVER; ANTIGEN; 85A; LIFE-SPAN; VACCINATION; KINETICS; TUBERCULOSIS; HUMANS; BCG;

D O I：

10.1016/j.jcpa.2009.09.008

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Immunological memory consists of expanded clones of T and B lymphocytes that show an increased rate of cell division and shortened telomeres compared with naive cells. However, exhaustion of clones is delayed by kinetic heterogeneity within clones and altered survival and up-reulation of telomerase. Prolonged maintenance of protective B-cell immunity is T-cell dependent and requires a balance between plasma cells and memory B cells. Protective T-cell immunity also requires correct quality of T cells and that they are located appropriately. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：S91 / S95

页数：5

共 32 条

[1] Opinion - Will telomere erosion lead to a loss of T-cell memory?
Akbar, AN
Beverley, PCL
Salmon, M
[J]. NATURE REVIEWS IMMUNOLOGY, 2004, 4 (09) : 737 - 743
[2] mTOR regulates memory CD8 T-cell differentiation
Araki, Koichi
Turner, Alexandra P.
Shaffer, Virginia Oliva
Gangappa, Shivaprakash
Keller, Susanne A.
Bachmann, Martin F.
Larsen, Christian P.
Ahmed, Rafi
[J]. NATURE, 2009, 460 (7251) : 108 - U124
[3] In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination
Bayry, Jagadeesh
Tchilian, Elma Z.
Davies, Matthew N.
Forbes, Emily K.
Draper, Simon J.
Kaveri, Srini V.
Hill, Adrian V. S.
Kazatchkine, Michel D.
Beverley, Peter C. L.
Flower, Darren R.
Tough, David F.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (29) : 10221 - 10226
[4] The PPD-specific T-cell clonal response in UK and Malawian subjects following BCG vaccination: A new repertoire evolves over 12 months
Bennett, AR
Gorak-Stolinska, P
Ben-Smith, A
Floyd, S
de Lara, CM
Weir, RE
Lalor, MK
Makamo, K
Msiska, GK
Crampin, AC
Fine, PEM
Dockrell, HM
Beverley, PCL
[J]. VACCINE, 2006, 24 (14) : 2617 - 2626
[5] Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
Darrah, Patricia A.
Patel, Dipti T.
De Luca, Paula M.
Lindsay, Ross W. B.
Davey, Dylan F.
Flynn, Barbara J.
Hoff, Soren T.
Andersen, Peter
Reed, Steven G.
Morris, Sheldon L.
Roederer, Mario
Seder, Robert A.
[J]. NATURE MEDICINE, 2007, 13 (07) : 843 - 850
[6] KINETICS OF B-CELL SUBPOPULATIONS IN PERIPHERAL LYMPHOID-TISSUES - EVIDENCE FOR THE PRESENCE OF PHENOTYPICALLY DISTINCT SHORT-LIVED AND LONG-LIVED B-CELL SUBSETS
DEENEN, GJ
KROESE, FGM
[J]. INTERNATIONAL IMMUNOLOGY, 1993, 5 (07) : 735 - 741
[7] Molecular mechanism and function of CD40/CD40L engagement in the immune system
Elgueta, Raul
Benson, Micah J.
de Vries, Victor C.
Wasiuk, Anna
Guo, Yanxia
Noelle, Randolph J.
[J]. IMMUNOLOGICAL REVIEWS, 2009, 229 : 152 - 172
[8] Plasma cell development: From B-cell subsets to long-term survival niches
Fairfax, Kirsten A.
Kallies, Axel
Nutt, Stephen L.
Tarlinton, David M.
[J]. SEMINARS IN IMMUNOLOGY, 2008, 20 (01) : 49 - 58
[9] Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice
Forbes, Emily K.
Sander, Clare
Ronan, Edward O.
McShane, Helen
Hill, Adrian V. S.
Beverley, Peter C. L.
Tchilian, Elma Z.
[J]. JOURNAL OF IMMUNOLOGY, 2008, 181 (07) : 4955 - 4964
[10] B cell life span: A review
Fulcher, DA
Basten, A
[J]. IMMUNOLOGY AND CELL BIOLOGY, 1997, 75 (05) : 446 - 455

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