N-terminal pro-B-type natriuretic peptide and cardiac troponin T in non-immune hydrops

被引:6
|
作者
Lee, Seung Mi [1 ,2 ]
Jun, Jong Kwan [1 ]
Kim, Su Ah [1 ]
Kang, Min Ji [1 ]
Song, Sang Hoon [3 ]
Lee, JoonHo [1 ]
Park, Chan-Wook [1 ]
Park, Joong Shin [1 ]
机构
[1] Seoul Natl Univ, Dept Obstet & Gynecol, Coll Med, Seoul 110744, South Korea
[2] Seoul Natl Univ, Dept Lab Med, Coll Med, Seoul, South Korea
[3] Seoul Metropolitan Govt Seoul Natl Univ, Boramae Med Ctr, Dept Obstet & Gynecol, Seoul, South Korea
关键词
cardiac troponin T; congenital heart disease; cord blood; N-terminal pro-B-type natriuretic peptide; non-immune hydrops; FETAL CIRCULATION; HEART-FAILURE; ETIOLOGY; NEWBORNS; PRESSURE; FETUSES; BNP;
D O I
10.1111/jog.12920
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
AimWe analyzed the N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in non-immune hydrops cases, to determine whether congestive heart failure or inadequate cardiac output may be mechanisms underlying abnormal fluid collection in hydrops. MethodsThe study population consisted of singleton neonates with non-immune hydrops and healthy control neonates, matched for both gestational age at delivery and mode of delivery. The subjects were divided into three groups: group 1, hydrops of cardiac origin (n=6); group 2, hydrops of non-cardiac origin (n=17); and group 3, control (n=23). The NT-proBNP and cTnT were measured in the cord blood collected at the time of delivery. ResultsThe median cord blood concentrations of NT-proBNP and cTnT were not different between the hydrops (groups 1 and 2) or control cases. However, the NT-proBNP level was elevated in group 1 compared with groups 2 and 3. The concentrations of cTnT did not differ among the three groups. ConclusionsThe concentration of NT-proBNP was only elevated in cases of hydrops of cardiac origin. Congestive heart failure might not be the underlying mechanism of fluid collection in cases of non-immune hydrops of non-cardiac origin, and NT-proBNP may be a promising tool to differentiate the origin of hydrops.
引用
收藏
页码:380 / 384
页数:5
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