Aziridine 2-carboxylate ester mediated asymmetric synthesis of alpha-alkyl beta-amino acids

被引：47
作者：
Davis, FA
Reddy, GV
Liang, CH
机构：
[1] Department of Chemistry, Temple University, Philadelphia
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 29期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0040-4039(97)01095-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The highly stereoselective ring opening of N-tosylaziridine 2-carboxylate esters with LiAlH4 followed by oxidation of the ensuing syn alcohols results in a highly efficient 4 step asymmetric synthesis of alpha-methyl beta-amino acids from N-sulfinylaziridine 2-carboxylate esters. (C) 1997 Elsevier Science Ltd.
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页码：5139 / 5142
页数：4
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