Necdin and TrkA contribute to modulation by p75NTR of resistance to oxidant stress

被引：8
作者：
Ingraham, Christopher A. [1 ]
Schor, Nina F. [1 ]
机构：
[1] Univ Rochester, Med Ctr, Dept Pediat, Rochester, NY 14642 USA
来源：
EXPERIMENTAL CELL RESEARCH | 2009年 / 315卷 / 20期
关键词：
p75NTR; Necdin; TrkA; Oxidant stress; Neurotrophin receptors; NGF; NERVE GROWTH-FACTOR; AFFINITY NGF RECEPTOR; PRADER-WILLI-SYNDROME; NEUROTROPHIN RECEPTOR; NEUROBLASTOMA-CELLS; MEDIATED APOPTOSIS; EXPRESSION; ACTIVATION; SURVIVAL; MOUSE;
D O I：
10.1016/j.yexcr.2009.10.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The neurotrophin receptor p75NTR provides protection from oxidant stress induced by 6-hydroxydopamine (6-OHDA) and resultant cell death. in the absence of p75NTR, TrkA is upregulated and its signaling pathway effectors are increasingly activated. Necdin, a MAGE protein and known interactor of p75NTR and TrkA, is a potential mediator of this phenomenon. Decreased expression of necdin protein in p75NTR-deficient PC12 cells decreased TrkA expression and increased PC12 cell resistance to 6-OHDA. Inhibition of JNK phosphorylation by SP600125 also resulted in increased resistance to 6-OHDA, suggesting that TrkA signaling underlies the susceptibility of these cells to oxidant stress. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：3532 / 3542
页数：11
相关论文
共 32 条
  • [1] EXPRESSION OF NECDIN, AN EMBRYONAL CARCINOMA-DERIVED NUCLEAR-PROTEIN, IN DEVELOPING MOUSE-BRAIN
    AIZAWA, T
    MARUYAMA, K
    KONDO, H
    YOSHIKAWA, K
    [J]. DEVELOPMENTAL BRAIN RESEARCH, 1992, 68 (02): : 265 - 274
  • [2] Expression of the Prader-Willi gene Necdin during mouse nervous system development correlates with neuronal differentiation and p75NTR expression
    Andrieu, D
    Watrin, F
    Niinobe, M
    Yoshikawa, K
    Muscatelli, F
    Fernandez, PA
    [J]. GENE EXPRESSION PATTERNS, 2003, 3 (06) : 761 - 765
  • [3] Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination
    Arévalo, Juan Carlos
    Waite, Janelle
    Rajagopal, Rithwick
    Beyna, Mercedes
    Chen, Zhe-Yu
    Lee, Francis S.
    Chao, Moses V.
    [J]. NEURON, 2006, 50 (04) : 549 - 559
  • [4] p75 neurotrophin receptor is required for constitutive and NGF-induced survival signalling in PC12 cells and rat hippocampal neurones
    Bui, NT
    König, HG
    Culmsee, C
    Bauerbach, E
    Poppe, M
    Krieglstein, J
    Prehn, JHM
    [J]. JOURNAL OF NEUROCHEMISTRY, 2002, 81 (03) : 594 - 605
  • [5] Coenzyme Q10 levels in Prader-Willi syndrome: Comparison with obese and non-obese subjects
    Butler, MG
    Dasouki, M
    Bittel, D
    Hunter, S
    Naini, A
    DiMauro, S
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2003, 119A (02): : 168 - 171
  • [6] Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75
    Carter, BD
    Kaltschmidt, C
    Kaltschmidt, B
    Offenhauser, N
    BohmMatthaei, R
    Baeuerle, PA
    Barde, YA
    [J]. SCIENCE, 1996, 272 (5261) : 542 - 545
  • [7] Casaccia-Bonnefil P, 1999, ADV EXP MED BIOL, V468, P275
  • [8] Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
    CasacciaBonnefil, P
    Carter, BD
    Dobrowsky, RT
    Chao, MV
    [J]. NATURE, 1996, 383 (6602) : 716 - 719
  • [9] Neurotrophins and their receptors: A convergence point for many signalling pathways
    Chao, MV
    [J]. NATURE REVIEWS NEUROSCIENCE, 2003, 4 (04) : 299 - 309
  • [10] The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation - Duration of JNK activation may determine cell death and proliferation
    Chen, YR
    Wang, XP
    Templeton, D
    Davis, RJ
    Tan, TH
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (50) : 31929 - 31936
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