Immunotherapy of Human Cancers Using Gene Modified T Lymphocytes

被引：26

作者：

Vera, Juan F. ^{[1
,2
]}

Brenner, Malcolm K. ^{[1
,2
,4
]}

Dotti, Gianpietro ^{[1
,2
,3
]}

机构：

[1] Baylor Coll Med, Ctr Cell & Gene Therapy, Methodist Hosp, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Med, Methodist Hosp, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Immunol, Methodist Hosp, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Pediat, Methodist Hosp, Houston, TX 77030 USA

来源：

CURRENT GENE THERAPY | 2009年 / 9卷 / 05期

关键词：

TUMOR-INFILTRATING LYMPHOCYTES; ENGINEERED DONOR LYMPHOCYTES; ORGAN TRANSPLANT RECIPIENTS; CHIMERIC RECEPTOR GENE; VIRUS-INDUCED LYMPHOMA; ANTITUMOR-ACTIVITY; ADOPTIVE TRANSFER; ANTIGEN RECEPTOR; CELL-RECEPTOR; SUICIDE-GENE;

D O I：

10.2174/156652309789753338

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.

引用

页码：396 / 408

页数：13

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