International study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson disease

被引：209

作者：

Martinez-Martin, P. ^{[1
,2
]}

Rodriguez-Blazquez, C. ^{[1
,2
]}

Abe, K. ^{[3
]}

Bhattacharyya, K. B. ^{[4
]}

Bloem, B. R. ^{[5
]}

Carod-Artal, F. J. ^{[6
]}

Prakash, R. ^{[7
]}

Esselink, R. A. J. ^{[5
]}

Falup-Pecurariu, C. ^{[8
]}

Gallardo, M. ^{[9
]}

Mir, P. ^{[10
]}

Naidu, Y. ^{[11
]}

Nicoletti, A. ^{[12
]}

Sethi, K. ^{[7
]}

Tsuboi, Y. ^{[13
]}

van Hilten, J. J. ^{[14
]}

Visser, M. ^{[14
]}

Zappia, M. ^{[12
]}

Chaudhuri, K. R. ^{[15
]}

机构：

[1] Carlos III Inst Hlth, Natl Ctr Epidemiol, Madrid 28029, Spain

[2] Carlos III Inst Hlth, CIBERNED, Madrid 28029, Spain

[3] Konan Womens Univ, Dept Neurol & Rehabil, Kobe, Hyogo, Japan

[4] Burdwan Med Coll & Hosp, Bangur Inst Neurosci & Psychiat, Dept Neuromed, Kolkata, W Bengal, India

[5] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Neurol, NL-6525 ED Nijmegen, Netherlands

[6] Sarah Hosp, Dept Neurol, Brasilia, DF, Brazil

[7] Med Coll Georgia, Dept Neurol, Augusta, GA 30912 USA

[8] Transilvania Univ, Dept Neurol, Brasov, Romania

[9] Hosp Domingo Dr Luciani, Movement Disorders Unit, Caracas, Venezuela

[10] Hosp Univ Virgen Rocio CSIC U Sevilla, Inst Biomed Sevilla, Dept Neurol, Movement Disorders Unit, Seville, Spain

[11] Univ Hosp, Dept Neurol, London, England

[12] Univ Catania, Dept Neurosci, I-95124 Catania, Italy

[13] Fukuoka Univ Hosp, Dept Neurol, Fukuoka, Japan

[14] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RA Leiden, Netherlands

[15] Kings Coll Hosp London, Natl Parkinson Fdn Ctr Excellence, London, England

来源：

NEUROLOGY | 2009年 / 73卷 / 19期

关键词：

QUALITY-OF-LIFE; INDEX; QUESTIONNAIRE; HALLUCINATIONS; COEFFICIENT; PREVALENCE; VALIDATION; IMPRESSION; SEVERITY;

D O I：

10.1212/WNL.0b013e3181c0d416

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Nonmotor symptoms (NMS) have a great impact on patients with Parkinson disease (PD). The Non-Motor Symptoms Scale (NMSS) is an instrument specifically designed for the comprehensive assessment of NMS in patients with PD. NMSS psychometric properties have been tested in this study. Methods: Data were collected in 12 centers across 10 countries in America, Asia, and Europe. In addition to the NMSS, the following measures were applied: Scales for Outcomes in Parkinson's Disease (SCOPA)-Motor, SCOPA-Psychiatric Complications (SCOPA-PC), SCOPA-Cognition, Hoehn and Yahr Staging (HY), Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD), SCOPA-Autonomic, Parkinson's Disease Sleep Scale (PDSS), Parkinson's Disease Questionnaire-39 items (PDQ-39), and EuroQol-5 dimensions (EQ-5D). NMSS acceptability, reliability, validity, and precision were analyzed. Results: Four hundred eleven patients with PD, 61.3% men, were recruited. The mean age was 64.5 +/- 9.9 years, and mean disease duration was 8.1 +/- 5.7 years. The NMSS score was 57.1 +/- 44.0 points. The scale was free of floor or ceiling effects. For domains, the Cronbach alpha coefficient ranged from 0.44 to 0.85. The intraclass correlation coefficient (0.90 for the total score, 0.67-0.91 for domains) and Lin concordance coefficient (0.88) suggested satisfactory reproducibility. The NMSS total score correlated significantly with SCOPA-Autonomic, PDQ-39, and EQ-5D (r(S) = 0.57-0.70). Association was close between NMSS domains and the corresponding SCOPA Autonomic domains (r(S) = 0.51-0.65) and also with scales measuring related constructs ( PDSS, SCOPA-PC) (all p < 0.0001). The NMSS total score was higher for women (p < 0.02) and for increasing disease duration, HY, and CISI-PD severity level (p < 0.001). The SEM was 13.91 for total score and 1.71 to 4.73 for domains. Conclusion: The Non-Motor Symptoms Scale is an acceptable, reproducible, valid, and precise assessment instrument for nonmotor symptoms in Parkinson disease. Neurology (R) 2009; 73: 1584-1591

引用

页码：1584 / 1591

页数：8

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