Low titer, isolated anti Ro/SSA 60 kd antibodies is correlated with positive pregnancy outcomes in women at risk of congenital heart block

被引：7

作者：

Tonello, Marta ^{[1
]}

Hoxha, Ariela ^{[1
]}

Mattia, Elena ^{[1
]}

Zambon, Alessandra ^{[2
]}

Visentin, Silvia ^{[2
]}

Cerutti, Alessia ^{[3
]}

Ghirardello, Anna ^{[1
]}

Milanesi, Ornella ^{[3
]}

Ruffatti, Amelia ^{[1
]}

机构：

[1] Univ Padua, Dept Med, Rheumatol Unit, Padua, Italy

[2] Univ Padua, Dept Womens & Childrens Hlth, Gynaecol & Obstet Unit, Padua, Italy

[3] Univ Padua, Dept Womens & Childrens Hlth, Paediat Cardiol Unit, Padua, Italy

来源：

CLINICAL RHEUMATOLOGY | 2017年 / 36卷 / 05期

关键词：

Anti-Ro/SSA; 60; kd; 52kd; Anti-p200; Anti-La/SSB; Isolated autoantibodies; Congenital heart block; NEONATAL LUPUS; RO; AUTOANTIBODIES; SSA/RO; MOTHERS; SURFACE;

D O I：

10.1007/s10067-017-3572-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Congenital heart block (CHB) is an autoantibody mediated disorder presumably caused by placental transmission of maternal autoantibodies to Ro/SSA 52 kd, p200, Ro/SSA 60 kd, La/SSB ribonucleoproteins. This study investigated the clinical significance of isolated anti-Ro/SSA 52 kd, anti-p200, anti-Ro/SSA 60 kd, and anti-La/SSB antibodies in positive pregnant patients. One hundred sixty-three pregnant women positive to anti-Ro/SSA 52 kd and/or anti-Ro/SSA 60 kd and/or anti-La/SSB antibodies were prospectively enrolled in the study. Anti-Ro52, anti-Ro60, anti-p200, and anti-La antibodies were assayed using home-made ELISA assays. Isolated antibody positivity was found in 25 women (15.3%), while multiple antibody positivity in 138 (84.7%). Twenty-four developed CHB, and the 139 had a favorable pregnancy outcome. The prevalence of isolated anti-Ro/SSA 60 kd antibodies was significantly higher (p < 0.046) as the prevalence of lower mean antibody titers (p < 0.0001) in the later group. Confirmation of these results by large-scale studies could lead clinicians to recommend less stringent fetal echocardiography monitoring in women with isolated anti-Ro/SSA 60 kd antibodies.

引用

页码：1155 / 1160

页数：6

共 29 条

[1] Molecular mechanisms of congenital heart block [J].