Electrochemical sensors targeting salivary biomarkers: A comprehensive review

被引：113
作者：
Mani, Veerappan [1 ]
Beduk, Tutku [1 ]
Khushaim, Walaa [1 ]
Ceylan, Ayse Elcin [2 ]
Timur, Suna [2 ]
Wolfbeis, Otto S. [3 ]
Salama, Khaled Nabil [1 ]
机构：
[1] King Abdullah Univ Sci & Technol KAUST, Comp Elect & Math Sci & Engn CEMSE Div, Adv Membranes & Porous Mat Ctr AMPMC, Sensors Lab, Thuwal, Saudi Arabia
[2] Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey
[3] Univ Regensburg, Inst Analyt Chem Chemo & Biosensors, D-93040 Regensburg, Germany
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2021年 / 135卷
关键词：
Clinical diagnostics; Saliva; Biomarker; Biosensor; Viral disease; Cardiovascular disease; Cancer; Drug abuse; Wearable sensors; Microfluidics;
D O I：
10.1016/j.trac.2020.116164
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The analysis of salivary markers has grown into a promising non-invasive route for easy, safe, and pain-free monitoring and has the potential to alter the existing way of clinical diagnosis and management. Advancements in sensing technology, the arrival of novel materials, the innovative fabrication technologies, and sampling accuracy have made significant progress and establishing saliva as a fluid for routine analysis. Salivary biomarkers are useful to diagnose not only cardiovascular diseases, bacterial or viral infections but also cancer, diabetes, or Alzheimer's disease. In addition, saliva is analyzed in toxicology, forensic medicine and drug abuse. Electrochemical assays and sensors are well accepted tools because they allow for fast and cost-effective analysis. Nanomaterials, microfluidics, smartphones, paper-based, flexible and wearable devices have made significant advancements in saliva analysis. This review discusses the recent progress made in electrochemical methodologies for detecting salivary biomarkers. (C) 2020 Elsevier B.V. All rights reserved.
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页数：11
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