Factors for graft-versus-host disease after donor lymphocyte infusions with an escalating dose regimen:: lack of association with cell dose

被引：21

作者：

Fozza, C. ^{[1
]}

Szydlo, R. M. ^{[1
]}

Abdel-Rehim, M. M. ^{[1
]}

Nadal, E. ^{[1
]}

Goldman, J. M. ^{[1
]}

Apperley, J. F. ^{[1
]}

Dazzi, F. ^{[1
]}

机构：

[1] Hammersmith Hosp, Imperial Coll, Fac Med, Dept Haematol, London W12 0NN, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 136卷 / 06期

关键词：

allogeneic stem cell transplantation; chronic myeloid leukaemia; donor lymphocyte infusions; graft-versus-host disease;

D O I：

10.1111/j.1365-2141.2007.06501.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the risk factors for graft-versus-host disease (GVHD) in 82 patients treated with donor lymphocyte infusions (DLI) using an escalating dose regimen for chronic myeloid leukaemia in relapse following conventional allografting. Two factors emerged as predictors of both acute and chronic GVHD: the infusion of male recipients with lymphocytes from a female donor and the interval between transplant and last DLI, but only the first remained significant at multivariate analysis. Surprisingly, lymphocyte dose did not influence the incidence of GVHD. Our results suggest that DLI can be given in large cell doses without increasing the risk of GVHD.

引用

页码：833 / 836

页数：4

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