Primary cutaneous anaplastic large-cell lymphoma presenting with hemophagocytic syndrome: A case report and review of the literature

被引：14

作者：

Shimizua, Yoko ^{[1
]}

Tanae, Ken ^{[1
]}

Takahashi, Naoki ^{[1
]}

Kohri, Mika ^{[1
]}

Arai, Eiichi ^{[2
]}

Bessho, Masami ^{[1
]}

Niitsu, Nozomi ^{[1
]}

机构：

[1] Saitama Med Univ, Dept Hematol, Ctr Comprehens Canc, Int Med Ctr, Hidaka, Saitama 3501298, Japan

[2] Saitama Med Univ, Dept Pathol, Hidaka, Saitama 3501298, Japan

来源：

LEUKEMIA RESEARCH | 2010年 / 34卷 / 02期

关键词：

Primary cutaneous anaplastic large lymphoma; ALK-negative; Hemophagocytic syndrome; LYMPHOPROLIFERATIVE DISORDERS; FEATURES;

D O I：

10.1016/j.leukres.2009.07.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Primary cutaneous anaplastic large-cell lymphoma(C-ALCL) is a rare entity of lymphoma. We report a case of C-ALCL presenting with hemophagocytic syndrome and skin lesion with giant ulcer. Histopathological examination of the skin biopsy specimens showed non-epidermotropic in filtrates with cohesive sheets of large tumor cells. The tumor cells showed CD4-, CD8+, CD30+, CD56-, ALK-, TIA-1+, and granzyme B+. C-ALCL is generally a disorder that progresses slowly and has a good prognosis. Manifestation of a giant ulcer and hemophagocytic syndrome, such as in the present case, is rare. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：263 / 266

页数：4

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