Understanding the Role of DISC1 in Psychiatric Disease and during Normal Development

被引：148

作者：

Brandon, Nicholas J. ^{[1
]}

Millar, J. Kirsty ^{[2
,3
]}

Korth, Carsten ^{[4
]}

Sive, Hazel ^{[5
,6
,7
]}

Singh, Karun K. ^{[11
]}

Sawa, Akira ^{[8
,9
,10
]}

机构：

[1] Wyeth Ayerst Res, Discovery Neurosci, Princeton, NJ 08543 USA

[2] Univ Edinburgh, Med Genet Sect, Ctr Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland

[3] Univ Edinburgh, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland

[4] Univ Dusseldorf, Dept Neuropathol, Sch Med, D-40225 Dusseldorf, Germany

[5] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[6] MIT, Cambridge, MA 02142 USA

[7] Broad Inst, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA

[8] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[9] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[10] Johns Hopkins Univ, Sch Med, Program Cellular & Mol Med, Baltimore, MD 21205 USA

[11] MIT, Picower Inst Learning & Memory, Cambridge, MA 02139 USA

来源：

JOURNAL OF NEUROSCIENCE | 2009年 / 29卷 / 41期

基金：

英国医学研究理事会;

关键词：

DENDRITIC SPINE MORPHOGENESIS; SCHIZOPHRENIA-1; DISC1; MOLECULAR-MECHANISMS; ACTIN CYTOSKELETON; NEURITE OUTGROWTH; BRAIN; PROTEIN; RISK; ASSOCIATION; MICE;

D O I：

10.1523/JNEUROSCI.3355-09.2009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The biology of schizophrenia is complex with multiple hypotheses (dopamine, glutamate, neurodevelopmental) well supported to underlie the disease. Pathways centered on the risk factor "disrupted in schizophrenia1"(DISC1) may be able to explain and unite these disparate hypotheses and will be the topic of this mini-symposium preview. Nearly a decade after its original identification at the center of a translocation breakpoint in a large Scottish family that was associated with major psychiatric disease, we are starting to obtain credible insights into its function and role in disease etiology. This preview will highlight a number of exciting areas of current DISC1 research that are revealing roles for DISC1 during normal brain development and also in the disease state. Together these different threads will provide a timely and exciting overview of the DISC1 field and its potential in furthering our understanding of psychiatric diseases and in developing new therapies.

引用

页码：12768 / 12775

页数：8

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