LOW-INTENSITY PULSED ULTRASOUND PROMOTES EXERCISE-INDUCED MUSCLE HYPERTROPHY

被引：11
|
作者：
Tang, Liang [1 ]
Zhang, Jing [1 ]
Zhao, Xinjuan [1 ]
Li, Nan [1 ]
Jian, Wenqi [1 ]
Sun, Shuxin [2 ]
Guo, Jianzhong [3 ]
Sun, Lijun [1 ]
Ta, Dean [2 ,4 ,5 ]
机构：
[1] Shaanxi Normal Univ, Inst Sports Biol, Xian 710119, Peoples R China
[2] Fudan Univ, Dept Elect Engn, Shanghai, Peoples R China
[3] Shaanxi Normal Univ, Shaanxi Key Lab Ultrason, Xian, Peoples R China
[4] Fudan Univ, State Key Lab ASIC & Syst, Shanghai, Peoples R China
[5] Key Lab Med Imaging Comp & Comp Assisted Interven, Shanghai, Peoples R China
来源：
ULTRASOUND IN MEDICINE AND BIOLOGY | 2017年 / 43卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Low-intensity pulsed ultrasound; Treadmill exercise; Skeletal muscle hypertrophy; Protein catabolism; Protein synthesis; RAT SKELETAL-MUSCLE; INDUCED OBESE RATS; PROTEIN-SYNTHESIS; SIGNALING PATHWAYS; MYOBLAST DIFFERENTIATION; TRANSCRIPTION FACTORS; MYOSTATIN INHIBITORS; GASTROCNEMIUS-MUSCLE; RESISTANCE EXERCISE; INSULIN-RESISTANCE;
D O I：
10.1016/j.ultrasmedbio.2017.02.017
中图分类号：
O42 [声学];
学科分类号：
070206 ; 082403 ;
摘要：
The purpose of this study was to investigate whether low-intensity pulsed ultrasound (LIPUS) promotes exercise-induced muscle hypertrophy. Twenty-four adult Sprague-Dawley (SD) rats were randomly assigned to three groups (n = 8 per group): normal control group (NC), treadmill exercise group (TE) and treadmill exercise + LIPUS group (TE + LIPUS). The TE + LIPUS group received a LIPUS treatment (1 MHz, 30 mW/cm(2)) at the gastrocnemius for 20 min/d after treadmill exercise. The TE group was sham-treated. Eight weeks of treadmill training successfully established the exercise-induced muscle hypertrophy model. Muscle strength, muscle mass and muscle fiber cross-sectional area were significantly increased in the TE1LIPUS group compared with the TE group. Moreover, LIPUS treatment significantly upregulated the expression of Akt, mTOR, p-Akt and p-mTOR and significantly downregulated the expression of MSTN, ActRIIB, FoxO1 and its phosphorylation. The results indicated that LIPUS promotes exercise-induced muscle hypertrophy by facilitating protein synthesis and inhibiting the protein catabolism pathway. (E-mail: sunlijun@snnu.edu.cn) (C) 2017 World Federation for Ultrasound in Medicine & Biology.
引用
收藏
页码：1411 / 1420
页数：10
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