Synthesis of Functionalized Isoquinolines via Sequential Cyclization/Cross-Coupling Reactions

被引：39
作者：
Yu, Xingxin [1 ]
Wu, Jie [1 ,2 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
[2] Chinese Acad Sci, Lab Organometall Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
来源：
JOURNAL OF COMBINATORIAL CHEMISTRY | 2009年 / 11卷 / 05期
基金：
中国国家自然科学基金;
关键词：
CATALYZED 3-COMPONENT REACTIONS; BENZODIAZEPINE-RECEPTOR; IRIDIUM COMPLEXES; 3,4-DISUBSTITUTED ISOQUINOLINES; ELECTROCHEMICAL PROPERTIES; ELECTROPHILIC CYCLIZATION; SUBSTITUTED ISOQUINOLINES; ASYMMETRIC CATALYSIS; TERMINAL ACETYLENES; ORGANIC-SYNTHESIS;
D O I：
10.1021/cc900079s
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
CuX2-mediated cyclization of 2-alkynylbenzaldehyde O-methyl oximes in N,N-dimethylacetamide (DMA) gave rise to 4-chloroisoquinolines in good yield, which underwent the palladium-catalyzed cross-coupling reactions of arylboronic acids subsequently to afford the functionalized isoquinolines.
引用
收藏
页码：895 / 899
页数：5
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