Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts

被引:308
作者
Nakagawa, M
Kaneda, T
Arakawa, T
Morita, S
Sato, T
Yomada, T
Hanada, K
Kumegawa, M
Hakeda, Y [1 ]
机构
[1] Meikai Univ, Sch Dent, Dept Oral Anat, Sakado, Saitama 3500283, Japan
[2] Niigata Univ, Sch Dent, Dept Orthodont, Niigata 951, Japan
[3] Meikai Univ, Sch Dent, Dept Internal Med, Sakado, Saitama 3500283, Japan
关键词
vascular endothelial growth factor; osteoclast; bone resorption; KDR/Flk-1; Flt-1;
D O I
10.1016/S0014-5793(00)01520-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In bone development and regeneration, angiogenesis and bone/cartilage resorption are essential processes and are closely associated with each other, suggesting a common mediator for these two biological events. To address this interrelationship, we examined the effect of vascular endothelial growth factor (VEGF), the most critical growth factor for angiogenesis, on osteoclastic bone-resorbing activity in a culture of highly purified rabbit mature osteoclasts, VEGF caused a dose- and time-dependent increase in the area of bone resorption pits excavated by the isolated osteoclasts, partially by enhancing the survival of the cells. Two distinct VEGF receptors, KDR/Flk-1 and Flt-1, were detectable in osteoclasts at the gene and protein levels, and VEGF induced tyrosine phosphorylation of proteins in osteoclasts. Thus, osteoclastic function and angiogenesis are upregulated by a common mediator such as VEGF, (C) 2000 Federation of European Biochemical Societies.
引用
收藏
页码:161 / 164
页数:4
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