Function and Evolution of Upstream ORFs in Eukaryotes

被引：107

作者：

Zhang, Hong ^{[1
]}

Wang, Yirong ^{[1
]}

Lu, Jian ^{[1
]}

机构：

[1] Peking Univ, Ctr Bioinforrnat, Sch Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2019年 / 44卷 / 09期

基金：

中国国家自然科学基金;

关键词：

OPEN READING FRAMES; MESSENGER-RNA DECAY; TRANSLATION INITIATION; TRANSPOSABLE ELEMENTS; PROFILING REVEALS; PROTEIN-SYNTHESIS; 5'-UNTRANSLATED REGIONS; START CODONS; IN-VIVO; EXPRESSION;

D O I：

10.1016/j.tibs.2019.03.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study.

引用

页码：782 / 794

页数：13

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