Purpose: To determine the long-term incidence of postirradiation hypothyroidism (HT) in patients with head-and-neck cancer. Methods and Materials: The incidence of overt HT was assessed prospectively in 391 patients with nonthyroid head-and-neck cancer admitted for radiotherapy (RT) consecutively between 1990 and 1996. Eighty-three patients were excluded from the analysis because of known thyroid disease before treatment (n = 27), no RT was given (n = 15), or inadequate follow-up (n = 41). Overt HT was defined as increased thyroid-stimulating hormone (TSH) in combination with decreased fT4/T4 or in combination with initiation of thyroxine replacement therapy. Results: With a median follow-up of 4.2 years (range, 3 months to 10.9 years) for 308 evaluable patients, the 5- and 10-year Kaplan-Meier actuarial risks of HT were 20% and 27%, respectively. The median time until development of HT was 1.8 years (3 months to 8.1 years). Multivariate analysis showed that patients with bilateral RT to the neck had a higher risk of HT in comparison with unilateral neck RT (relative hazard, 0.37; p = 0.02). The addition of surgery to RT increased the overall risk of HT (p < 0.001); and if surgery involved the thyroid gland, the relative hazard was 4.74 (p < 0.001). For an elevated pre-RT TSH value, the relative hazard was 1.58 (p < 0.001). Conclusion: The incidence of overt HT after locoregional RT for nonthyroid head-and-neck cancer continues to increase with time, even after long-term follow-up. We recommend life-long TSH testing in these patients. (C) 2004 Elsevier Inc.
